Parkinson ê pēⁿ
Pa-kin-sng-pēⁿ (Ji̍t-gí:パーキンソンびょう, Eng-gí:Parkinson’s disease) sī chi̍t-chióng bān-sèng náu-kin thè-hoà ê chi̍t-pēⁿ, tiāⁿ-tiāⁿ ē hóng-gāi hoān-chiá ūn-tōng kap kóng-oē ê lêng-le̍k. Tī 1817 nî, Eng-kok ê James Parkinson i-su kā i thê-chhut. Pa-kin-sng-pēⁿ sī pa-kin-sng-chèng (Eng-gí:parkinsonism) kî-tiong siāng-chia̍p khoàiⁿ ê chi̍t-chióng.
| Parkinson's disease | |
|---|---|
| Other names | Parkinson disease, idiopathic or primary parkinsonism, hypokinetic rigid syndrome, paralysis agitans, shaking palsy |
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| Illustration of (advanced) Parkinson's disease by William Richard Gowers, first published in A Manual of Diseases of the Nervous System (1886), and based on 1879 photographs attributed to Albert Londe[1][2] | |
| Specialty | Neurology |
| Symptoms | Tremor, rigidity, slowness of movement, difficulty walking[3] |
| Complications | Dementia, depression, anxiety,[4] eating problems, and sleep problems[5] |
| Usual onset | Age over 60[3][6] |
| Causes | Unknown[7] |
| Risk factors | Pesticide exposure, head injuries[7] |
| Diagnostic method | Based on symptoms[3] |
| Differential diagnosis | Dementia with Lewy bodies, progressive supranuclear palsy, essential tremor, antipsychotic use[8] |
| Treatment | Medications, surgery[3] |
| Medication | L-DOPA, dopamine agonists[4] |
| Prognosis | Life expectancy about 7–15 years[9] |
| Frequency | 6.2 million (2015)[10] |
| Deaths | 117,400 (2015)[11] |
| Named after | James Parkinson |
Chèng-thâu
Chit-ê pēⁿ ê chèng-thâu kah ūn-tōng kong-lêng chiòng-gāi ū-tî-tāi, chú-iàu-ê ū 4 ê:
- hoān-chiá tiām-chēng ē sin-thé phî-phî-chhoah (resting tremor),
- sin-khu ngē-chiáⁿ (rigidity),
- kha-chhiú-bān-tūn (bradykinesia),
- kha-pō͘ thām-thē.
Kî-thaⁿ chhù-iàu ê chèng-thâu koh-ū: siá-jī sè-sè-jī-á, piáu-chêng chiâⁿ-chió, chiâⁿ-chió nih-ba̍k-chiu, thun-chia̍h-mi̍h thun-bô-sáⁿ-ē-lo̍h, kóng-oē sè-sè-siaⁿ-á, kiâⁿ-lō͘ sè-kah-pō͘-á, jú-kiâⁿ sī jú-kín, kiâⁿ-lō͘ koh chhiú bē hài-tín-tāng, téng-téng. Chit-ê pēⁿ mā-ū kah chū-chú sîn-keng hē-thóng chiòng-gāi ū-tî-tāi ê chèng-thâu, chhin-chhiūⁿ chu-thài-sèng kē-hiat-ap, piān-pì, kap sēng-kong-lêng chiòng-gāi, téng-téng; mā-ū kah kám-kak kong-lêng koh-iūⁿ ū-tî-tāi ê chèng-thâu, chhiūⁿ-kóng chhiú-kap-kha thàng-thiàⁿ, phái-phīⁿ-chhoē (hiù-kak koh-iūⁿ), chit-koá-á.
In-toaⁿ khí-lí
Chit-ê pēⁿ ê in-toaⁿ khí-lí ah-bô chiâⁿ hun-bêng, lâng leh kóng sī kah náu-kin ē-té ê basal ganglia kap substantial nigra ê náu-sè-pau khoài-kín thè-hoà, bô-hoat-tō͘ seⁿ-sêng ū-kàu-giah ê sîn-keng ín-chhoā bu̍t-chit, hō-chò tô-phá-mín (Eng-gí:dopamine), a-sit-toh-kho-lín (Eng-gí: acetylcholine) ê chok-iōng cheng-ka ū tî-tāi. Náu-kin lāi-té su-iàu tô-phá-mín lâi chhoā-chhau ki-bah ê oa̍h-tōng, nā tô-phá-mín bô kàu-gia̍h tio̍h-ē sán-seng chē-chē ê oa̍h-tōng chiòng-gāi.
Tī-liâu
Náu-chhim-pō͘ chhì-kek-liâu-hoat
Náu-chhim-pō͘ chhì-kek-liâu-hoat (Eng-gí:Deep Brain Stimulation (DBS) ) sī chit cha̍p-kúi-nî lâi tī-liâu Pa-kin-sng-pēⁿ ê sin hoat-tō͘, kah io̍h-bu̍t tī-liâu tâng-chê chò-hoé sú-iōng, ē-sái-tit kái-siān pēⁿ-chêng chiâⁿ-chē.