SIRT1

SIRT1 (англ. Sirtuin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми.^[4] Довжина поліпептидного ланцюга білка становить 747 амінокислот, а молекулярна маса — 81 681^[5].

SIRT1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR
Ідентифікатори
Символи	SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1
Зовнішні ІД	OMIM: 604479 MGI: 2135607 HomoloGene: 56556 GeneCards: SIRT1
Реагує на сполуку
SRT1720[1]
Онтологія гена Молекулярна функція • GO:0001106 transcription corepressor activity • protein domain specific binding • core promoter sequence-specific DNA binding • protein C-terminus binding • keratin filament binding • transcription factor binding • зв'язування з іоном металу • HLH domain binding • enzyme binding • protein deacetylase activity • GO:0031493 histone binding • GO:0001948, GO:0016582 protein binding • NAD-dependent histone deacetylase activity • NAD-dependent protein deacetylase activity • histone deacetylase activity • p53 binding • mitogen-activated protein kinase binding • deacetylase activity • bHLH transcription factor binding • NAD+ binding • identical protein binding • NAD+ ADP-ribosyltransferase activity • hydrolase activity • NAD-dependent histone deacetylase activity (H3-K9 specific) • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Клітинна компонента • цитоплазма • nuclear envelope • rDNA heterochromatin • chromatin silencing complex • мітохондрія • клітинне ядро • ESC/E(Z) complex • ядерце • Хроматин • нуклеоплазма • PML body • nuclear inner membrane • гіалоплазма Біологічний процес • cellular triglyceride homeostasis • positive regulation of MHC class II biosynthetic process • DNA synthesis involved in DNA repair • positive regulation of protein phosphorylation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • ритмічний процес • single strand break repair • muscle organ development • histone H3-K9 deacetylation • negative regulation of cellular response to testosterone stimulus • regulation of peroxisome proliferator activated receptor signaling pathway • cellular response to DNA damage stimulus • regulation of bile acid biosynthetic process • реплікація ДНК • negative regulation of TOR signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of glucose metabolic process • rDNA heterochromatin assembly • negative regulation of DNA damage response, signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • циркадний ритм • positive regulation of cellular senescence • Сперматогенез • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to ionizing radiation • negative regulation of helicase activity • cholesterol homeostasis • response to leptin • cellular response to hypoxia • triglyceride mobilization • negative regulation of prostaglandin biosynthetic process • proteasome-mediated ubiquitin-dependent protein catabolic process • GO:0097285 апоптоз • peptidyl-lysine deacetylation • negative regulation of fat cell differentiation • negative regulation of peptidyl-lysine acetylation • GO:0009373 regulation of transcription, DNA-templated • positive regulation of adaptive immune response • stress-induced premature senescence • negative regulation of androgen receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • GO:0001306 response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of gene expression • transcription, DNA-templated • negative regulation of cAMP-dependent protein kinase activity • pyrimidine dimer repair by nucleotide-excision repair • response to insulin • histone H3-K9 modification • positive regulation of macroautophagy • positive regulation of cholesterol efflux • Убіквітин-залежний протеоліз • negative regulation of cell growth • positive regulation of macrophage apoptotic process • rRNA processing • regulation of brown fat cell differentiation • negative regulation of phosphorylation • GO:0022415 viral process • GO:0100026 Репарація ДНК • negative regulation of neuron death • positive regulation of histone H3-K9 methylation • negative regulation of histone H3-K14 acetylation • negative regulation of protein kinase B signaling • диференціація клітин • ovulation from ovarian follicle • regulation of protein serine/threonine kinase activity • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • protein ADP-ribosylation • leptin-mediated signaling pathway • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • protein deacetylation • fatty acid homeostasis • protein destabilization • regulation of mitotic cell cycle • positive regulation of cAMP-dependent protein kinase activity • white fat cell differentiation • GO:1903106 positive regulation of insulin receptor signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • peptidyl-lysine acetylation • response to hydrogen peroxide • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of histone H4-K16 acetylation • positive regulation of endothelial cell proliferation • regulation of smooth muscle cell apoptotic process • behavioral response to starvation • cellular glucose homeostasis • cellular response to starvation • cellular response to tumor necrosis factor • GO:1900404 positive regulation of DNA repair • multicellular organism development • regulation of cell population proliferation • positive regulation of cell population proliferation • regulation of endodeoxyribonuclease activity • regulation of cellular response to heat • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • UV-damage excision repair • histone deacetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Ангіогенез • macrophage cytokine production • regulation of lipid storage • positive regulation of adipose tissue development • macrophage differentiation • transcription by RNA polymerase II • positive regulation of smooth muscle cell differentiation • negative regulation of histone H3-K9 trimethylation • positive regulation of apoptotic process • cellular response to hydrogen peroxide • histone H3 deacetylation • negative regulation of protein acetylation • regulation of apoptotic process • cellular response to leukemia inhibitory factor • positive regulation of angiogenesis • transforming growth factor beta receptor signaling pathway • positive regulation of blood vessel endothelial cell migration • negative regulation of cellular senescence Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	23411	93759
Ensembl	ENSG00000096717	ENSMUSG00000020063
UniProt	Q96EB6	Q923E4
RefSeq (мРНК)	NM_001142498 NM_001314049 NM_012238	NM_001159589 NM_001159590 NM_019812
RefSeq (білок)	NP_001135970 NP_001300978 NP_036370	NP_001153061 NP_062786
Локус (UCSC)	Хр. 10: 67.88 – 67.92 Mb	Хр. 10: 63.15 – 63.22 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до гідролаз, білків розвитку, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, біологічні ритми, процесинг рРНК, диференціація клітин, міогенез, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з НАД, іонами металів, іоном цинку. Локалізований у цитоплазмі, ядрі, мітохондрії.