නිකොටින්

නිකොටින්
Systematic (IUPAC) name
	(S)-3-[1-Methylpyrrolidin-2-yl]pyridine
Clinical data
Trade names	Nicorette, Nicotrol
AHFS/Drugs.com	Monograph
Pregnancy cat.	D (AU) D (US)
Legal status	Pharmacy Only (S2) (AU) GSL (UK) OTC (US)
Dependence liability	High
Routes	Inhalation; Insufflation; Oral – Buccal, Sublingual, and Ingestion; Transdermal; Rectal,
Pharmacokinetic data
Bioavailability	20 to 45% (oral), 53% (intranasal), 68% (transdermal)
Protein binding	<5%
Metabolism	Hepatic
Half-life	1-2 hours; 20 hours active metabolite (cotinine)
Excretion	Urine (10-20% (gum), pH-dependent; 30% (inhaled); 10-30% (intranasal))
Identifiers
CAS number	54-11-5 [??]
ATC code	N07BA01 සැකිල්ල:ATCvet
PubChem	CID 89594
IUPHAR ligand	2585
DrugBank	DB00184
ChemSpider	80863
UNII	6M3C89ZY6R
KEGG	D03365
ChEBI	CHEBI:18723
ChEMBL	CHEMBL3
Chemical data
Formula	C10H14N2
Mol. mass	162.12 g/mol
	SMILES CN(CCC1)[C@@H]1C2=CC=CN=C2;
	InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 ; Key:SNICXCGAKADSCV-JTQLQIEISA-N ;
Physical data
Density	1.01 g/cm³
Melt. point	-79 °C (-110 °F)
Boiling point	247 °C (477 °F)
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උ

Nicotine is a potent parasympathomimetic alkaloid found in the nightshade family of plants (Solanaceae) and a stimulant drug. It is a nicotinic acetylcholine receptor agonist. It is made in the roots and accumulates in the leaves of the plants.It constitutes approximately 0.6–3.0% of the dry weight of tobacco^[1] and is present in the range of 2–7 µg/kg of various edible plants.^[2]It functions as an antiherbivore chemical; consequently, nicotine was widely used as an insecticide in the past^[3]^[4]

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