Amphetamine

Amphetamine (pronunciation: ⁱ/æmˈfɛtəmiːn/; contractit frae alpha‑methylphenethylamine) is a potent central nervous seestem (CNS) stimulant o the phenethylamine class that is uised in the treatment o attention deficit hyperacteevity disorder (ADHD) an narcolepsy.

Amphetamine

Clinical data
AHFS/Drugs.com	entry
Leecence data	US FDA: Adderall
Pregnancy category	US: C (Risk nae ruled oot)
Dependence liability	Pheesical: none Psychological: moderate
Addiction liability	Moderate
Routes o admeenistration	Medical: oral, nasal inhalation Recreational: oral, nasal inhalation, insufflation, rectal, intravenous
ATC code	N06BA01 (WHO)
Legal status
Legal status	AU: S8 (Controlled) CA: Schedule I UK: Class B US: Schedule II UN: Psychotropic Schedule II Rx-anly
Pharmacokinetic data
Bioavailability	Rectal 95–100%; Oral 75–100%[1]
Protein bindin	15–40%[2]
Metabolism	CYP2D6,[3] DBH,[4][5][6] FMO3,[7][8] XM-ligase,[9] an ACGNAT[10]
Onset o action	Immediate
Biological hauf-life	D-amph:9–11h;[3][11] L-amph:11–14h[3][11]
Excretion	Renal; pH-dependent range: 1–75%[3]
Identifiers
IUPAC name (RS)-1-phenylpropan-2-amine (RS)-1-phenyl-2-aminopropane
Synonyms	α-methylphenethylamine
CAS Nummer	300-62-9 Y
PubChem CID	3007
IUPHAR/BPS	4804
DrugBank	DB00182 Y
ChemSpider	13852819 Y
UNII	CK833KGX7E
KEGG	D07445 Y
ChEBI	CHEBI:2679 Y
ChEMBL	CHEMBL405 Y
NIAID ChemDB	018564
PDB ligand	FRD (PDBe, RCSB PDB)
ECHA InfoCard	100.005.543
Chemical and physical data
Formula	C9H13N
Molar mass	135.2084 g/mol
3D model (Jmol)	Interactive eemage
Density	0.9±0.1 g/cm3
Meltin pynt	11.3 °C (52.3 °F) [12]
Bylin pynt	203 °C (397 °F) [13]
SMILES NC(CC1=CC=CC=C1)C
InChI InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3 Y Key:KWTSXDURSIMDCE-UHFFFAOYSA-N Y
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