SMAD3

هم‌ساخت ۳ مادران مخالف دکپنتاپلجیک (انگلیسی: Mothers against decapentaplegic homolog 3) یک پروتئین است که در انسان توسط ژن «SMAD3» واقع بر بازوی بلند کروموزوم ۱۵ کُدگذاری می‌شود.^[۴][۵]

SMAD3
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
معین‌کننده‌ها
نام‌های دیگر	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
شناسه‌های بیرونی	OMIM: 603109 MGI: 1201674 HomoloGene: 55937 GeneCards: SMAD3
موقعیت ژن (موش) کروموزوم کروموزوم ۹ (موش)[۱] نوار 9|9 C شروع 63,554,049 bp[۱] پایان 63,665,276 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • phosphatase binding • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • R-SMAD binding • co-SMAD binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • enzyme binding • transforming growth factor beta receptor binding • protein homodimerization activity • collagen binding • zinc ion binding • chromatin binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001948، GO:0016582 پیوند پروتئینی • double-stranded DNA binding • protein kinase binding • sequence-specific DNA binding • DNA binding • bHLH transcription factor binding • ubiquitin binding • identical protein binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • beta-catenin binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • DEAD/H-box RNA helicase binding • mineralocorticoid receptor binding • glucocorticoid receptor binding • primary miRNA binding • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity ترکیبات سلولی • سیتوپلاسم • هسته یاخته • heteromeric SMAD protein complex • SMAD protein complex • transcription regulator complex • receptor complex • پوسته یاخته • intracellular anatomical structure • نوکلئوپلاسم • nuclear inner membrane • سیتوزول • GO:0009327 protein-containing complex فرایند زیستی • somitogenesis • skeletal system development • ureteric bud development • endoderm development • regulation of transforming growth factor beta2 production • embryonic pattern specification • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of osteoblast differentiation • heart looping • positive regulation of chondrocyte differentiation • positive regulation of alkaline phosphatase activity • positive regulation of interleukin-1 beta production • pericardium development • regulation of binding • negative regulation of wound healing • activation of cysteine-type endopeptidase activity involved in apoptotic process • transforming growth factor beta receptor signaling pathway • negative regulation of inflammatory response • positive regulation of positive chemotaxis • negative regulation of cell population proliferation • negative regulation of fat cell differentiation • cell-cell junction organization • GO:0009373 regulation of transcription, DNA-templated • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • signal transduction involved in regulation of gene expression • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • nodal signaling pathway • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cell growth • regulation of immune response • positive regulation of transforming growth factor beta3 production • T cell activation • activin receptor signaling pathway • regulation of striated muscle tissue development • embryonic foregut morphogenesis • positive regulation of bone mineralization • بهبود زخم • negative regulation of apoptotic process • positive regulation of extracellular matrix assembly • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • GO:0019049، GO:0030683 mitigation of host defenses by virus • thyroid gland development • developmental growth • lens fiber cell differentiation • لایه‌زایی • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی • osteoblast differentiation • GO:1990744، GO:1990729 primary miRNA processing • negative regulation of osteoblast proliferation • osteoblast development • embryonic cranial skeleton morphogenesis • transdifferentiation • paraxial mesoderm morphogenesis • response to hypoxia • positive regulation of cell migration • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • GO:1901313 positive regulation of gene expression • immune system development • positive regulation of focal adhesion assembly • liver development • regulation of epithelial cell proliferation • positive regulation of stress fiber assembly • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of mitotic cell cycle • negative regulation of cytosolic calcium ion concentration • canonical Wnt signaling pathway • protein stabilization • transcription, DNA-templated • GO:1903363 negative regulation of protein catabolic process • protein deubiquitination • positive regulation of nitric oxide biosynthetic process • negative regulation of lung blood pressure • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cardiac muscle hypertrophy in response to stress • cellular response to transforming growth factor beta stimulus • cellular response to cytokine stimulus • positive regulation of protein import into nucleus • positive regulation of DNA-binding transcription factor activity • SMAD protein signal transduction • positive regulation of canonical Wnt signaling pathway • SMAD protein complex assembly • adrenal gland development منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	4088	17127
آنسامبل	ENSG00000166949	ENSMUSG00000032402
یونی‌پروت	P84022	Q8BUN5
RefSeq (mRNA)	NM_001145103، NM_001145104، NM_005902، XM_011521559 NM_001145102، NM_001145103، NM_001145104، NM_005902، XM_011521559	XM_006510819، XM_006510821 NM_016769، XM_006510819، XM_006510821
RefSeq (پروتئین)	NP_001138575، NP_001138576، NP_005893، XP_011519861، XP_011519862 NP_001138574، NP_001138575، NP_001138576، NP_005893، XP_011519861، XP_011519862	XP_006510882، XP_006510884 NP_058049، XP_006510882، XP_006510884
موقعیت (UCSC)	ن/م	Chr : 63.55 – 63.67 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

این پروتئین عضوی از خانواده بزرگ SMAD است که این نیز به نوبهٔ خود، جزئی از اَبَرخانوادهٔ فاکتور رشد تغییردهنده بتا است.

نقش این پروتئین، تعدیل پیام‌هایی است که توسط فاکتور رشد تغییردهنده بتا آغاز می‌شود و در تزاید، تمایز و مرگ سلول نقش دارد.^[۶][۷]