Zinc transporter ZIP1

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.^[5][6][7]

SLC39A1
Identifiers
Aliases	SLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs	OMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,959,099 bp[1] End 153,968,184 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,155,479 bp[2] End 90,160,919 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta Achilles tendon upper lobe of left lung right lung stromal cell of endometrium gallbladder right adrenal gland left adrenal gland Descending thoracic aorta ascending aorta Top expressed in prostate belly cord epidermis lip uterus placenta urinary bladder gallbladder duodenum stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion transmembrane transporter activity inorganic cation transmembrane transporter activity zinc ion transmembrane transporter activity signaling receptor binding Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process embryonic cranial skeleton morphogenesis metal ion transport zinc ion transmembrane transport cation transport zinc ion transport in utero embryonic development ion transport limb development transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27173 30791 Ensembl ENSG00000143570 ENSMUSG00000052310 UniProt Q9NY26 Q9QZ03 RefSeq (mRNA) NM_014437 NM_001271957 NM_001271958 NM_001271959 NM_001271960 NM_001271961 NM_013901 RefSeq (protein) NP_001258886 NP_001258887 NP_001258888 NP_001258889 NP_001258890 NP_055252 NP_038929 Location (UCSC) Chr 1: 153.96 – 153.97 Mb Chr 3: 90.16 – 90.16 Mb PubMed search [3] [4]
Wikidata
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The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.^[8]