YTHDF2

YTHDF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RDN, 4RDO, 4WQN
Identifiers
Aliases	YTHDF2, HGRG8, NY-REN-2, CAHL, YTH N6-methyladenosine RNA binding protein 2, DF2
External IDs	OMIM: 610640; MGI: 2444233; HomoloGene: 32302; GeneCards: YTHDF2; OMA:YTHDF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,769,775 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	131,939,614 bp
RNA expression pattern
	Top expressed in
	gonad; ; cerebellar vermis; ; quadriceps femoris muscle; ; ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; bone marrow cells; ; olfactory zone of nasal mucosa; ; skin of abdomen; ; ventricular zone;
	Top expressed in
	maxillary prominence; ; medial ganglionic eminence; ; mandibular prominence; ; hand; ; abdominal wall; ; cumulus cell; ; endocardial cushion; ; vas deferens; ; somite; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	N6-methyladenosine-containing RNA binding; protein binding; RNA binding;
Cellular component	cytosol; P-body; nucleus; cytoplasm; microtubule organizing center; cytoplasmic ribonucleoprotein granule;
Biological process	humoral immune response; positive regulation of cap-independent translational initiation; regulation of mRNA stability; embryonic morphogenesis; mRNA destabilization; oocyte maturation; negative regulation of Notch signaling pathway; endothelial to hematopoietic transition; regulation of hematopoietic stem cell differentiation; regulation of meiotic cell cycle process involved in oocyte maturation; cell differentiation; oogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51441
	213541
	ENSG00000198492
	ENSMUSG00000040025
	Q9Y5A9
	Q91YT7
	NM_016258; NM_001172828; NM_001173128
	NM_145393
	NP_001166299; NP_001166599; NP_057342
	NP_663368
	Wikidata
View/Edit Human	View/Edit Mouse

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene.^[5]

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

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YTHDF2

Contents

Function

See also

References

Further reading