UGT1A4

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.^[5][6][7]

UGT1A4
Identifiers
Aliases	UGT1A4, HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D, UGT1A4S, UDP glucuronosyltransferase family 1 member A4, UGT1-01, UGT-1A, UGT1A, hUG-BR1, UGT1, GNT1, UGT1.1, UGT1A1
External IDs	OMIM: 606429; MGI: 3032634; HomoloGene: 88621; GeneCards: UGT1A4; OMA:UGT1A4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 233,718,736 bp[1] End 233,773,300 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 88,093,734 bp[2] End 88,146,719 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum gallbladder mucosa of transverse colon human kidney olfactory zone of nasal mucosa urinary bladder mucosa of esophagus renal cortex zone of skin Top expressed in hepatobiliary system liver granulocyte urinary bladder uterus mouth lip spleen colon human kidney More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity protein heterodimerization activity enzyme binding glucuronosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process negative regulation of cellular glucuronidation heme catabolic process cellular glucuronidation xenobiotic glucuronidation metabolism negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process bilirubin conjugation flavonoid glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54657 394433 Ensembl ENSG00000244474 ENSMUSG00000089943 UniProt P22310 n/a RefSeq (mRNA) NM_007120 NM_201643 RefSeq (protein) NP_009051 n/a Location (UCSC) Chr 2: 233.72 – 233.77 Mb Chr 1: 88.09 – 88.15 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although it is more active on amines, steroids, and sapogenins.^[7]

It is the main enzyme responsible for glucuronidation of the anticonvulsant lamotrigine.^[8]