TIE1

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Structures	Swiss-model
Domains	InterPro

tyrosine kinase with immunoglobulin-like and EGF-like domains 1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol	TIE1
Alt. symbols	TIE, JTK14
NCBI gene	7075
HGNC	11809
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Other data
EC number	2.7.1.112
Locus	Chr. 1 p34-p33
Structures
Search for
Structures	Swiss-model
Domains	InterPro

TIE1
Identifiers
Aliases	TIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11
External IDs	OMIM: 600222; MGI: 99906; HomoloGene: 3957; GeneCards: TIE1; OMA:TIE1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,323,108 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,347,258 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lung; ; upper lobe of left lung; ; right lobe of thyroid gland; ; subcutaneous adipose tissue; ; left lobe of thyroid gland; ; body of uterus; ; left ventricle; ; right auricle; ; tibial nerve;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; left lung; ; ankle joint; ; right lung; ; interventricular septum; ; left lung lobe; ; right lung lobe; ; yolk sac; ; atrium; ; vein;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cytoplasm; receptor complex;
Biological process	plasma membrane fusion; response to retinoic acid; phosphorylation; in utero embryonic development; vasculogenesis; protein phosphorylation; negative regulation of cell migration; blood vessel development; angiogenesis; negative regulation of angiogenesis; mesoderm development; signal transduction; peptidyl-tyrosine phosphorylation; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7075
	21846
	ENSG00000066056
	ENSMUSG00000033191
	P35590
	Q06806
	NM_001253357; NM_005424
	NM_011587
	NP_001240286; NP_005415
	NP_035717
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.^[5]

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells^[6] and platelets.^[7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.^[8]

References

External links

Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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TIE1

Contents

Function

See also

References

External links