Tampramine

Tampramine
Clinical data
Routes of; administration	Oral
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine;
CAS Number	83166-17-0 ; 83166-18-1 (fumarate);
PubChem CID	54961;
ChemSpider	49631;
UNII	47GSE5RM8N;
CompTox Dashboard (EPA)	DTXSID00232203 ;
Chemical and physical data
Formula	C23H24N4
Molar mass	356.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4;

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.^[1]^[2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.^[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.^[2]

References

Clinical data

Routes of administration	Oral
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number	83166-17-0 83166-18-1 (fumarate)
PubChem CID	54961
ChemSpider	49631
UNII	47GSE5RM8N
CompTox Dashboard (EPA)	DTXSID00232203
Chemical and physical data
Formula	C₂₃H₂₄N₄
Molar mass	356.473 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4