TRIM23

TRIM23
Identifiers
Aliases	TRIM23, ARD1, ARFD1, RNF46, tripartite motif containing 23
External IDs	OMIM: 601747; MGI: 1933161; HomoloGene: 1251; GeneCards: TRIM23; OMA:TRIM23 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	65,625,975 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	104,339,880 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; frontal pole; ; Achilles tendon; ; corpus callosum; ; prefrontal cortex; ; Brodmann area 10; ; inferior ganglion of vagus nerve; ; lateral nuclear group of thalamus; ; Pars compacta; ; ventricular zone;
	Top expressed in
	spermatocyte; ; lobe of cerebellum; ; amygdala; ; dentate gyrus of hippocampal formation granule cell; ; intercostal muscle; ; lateral septal nucleus; ; mammillary body; ; triceps brachii muscle; ; superior frontal gyrus; ; hippocampus proper;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity; identical protein binding; GTPase activity; ubiquitin-protein transferase activity; protein binding; GDP binding; zinc ion binding; metal ion binding; nucleotide binding; GTP binding; transferase activity; nucleic acid binding;
Cellular component	endomembrane system; Golgi membrane; nucleus; lysosomal membrane; intracellular anatomical structure; membrane; lysosome; cytoplasm; Golgi apparatus; plasma membrane;
Biological process	protein ubiquitination; viral process; positive regulation of catalytic activity; immune system process; innate immune response; intracellular protein transport; Golgi to plasma membrane transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	373
	81003
	ENSG00000113595
	ENSMUSG00000021712
	P36406
	Q8BGX0
	NM_001656; NM_033227; NM_033228
	NM_030731; NM_001361538; NM_001361539
	NP_001647; NP_150230; NP_150231
	NP_001348467; NP_001348468
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.^[6]

Interactions

TRIM23 has been shown to interact with TRIM31,^[7] TRIM29^[7] and PSCD1.^[8]

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TRIM23

Contents

Function

Interactions

References

Further reading