Swimming at the 2022 European Aquatics Championships – Women's 400 metre individual medley

Prior to the competition, the existing world, European and championship records were as follows.

	Name	Nationality	Time	Location	Date
World record European record	Katinka Hosszú	Hungary	4:26.36	Rio de Janeiro	6 August 2016
Championship record			4:30.90	London	16 May 2016

The heats were started at 10:02^[3]

Rank	Heat	Lane	Name	Nationality	Time	Notes
1	2	5	Viktória Mihályvári-Farkas	Hungary	4:41.01	Q
2	1	3	Zsuzsanna Jakabos	Hungary	4:41.30	Q
3	1	5	Ilaria Cusinato	Italy	4:44.89	Q
4	2	4	Katinka Hosszú	Hungary	4:45.07
5	2	3	Sara Franceschi	Italy	4:45.55	Q
6	2	6	Freya Colbert	Great Britain	4:46.39	Q
7	1	2	Alba Vázquez	Spain	4:46.72	Q
8	2	2	Katie Shanahan	Great Britain	4:47.30	Q
9	1	6	Zoe Vogelmann	Germany	4:48.03	Q
10	1	4	Mireia Belmonte	Spain	4:48.18
11	1	8	Nikoleta Trníková	Slovakia	4:49.41
12	2	8	Lisa Nystrand	Sweden	4:50.40
13	2	7	Francesca Fresia	Italy	4:50.88
14	1	1	Alexandra Dobrin	Romania	4:51.17
15	1	7	Giulia Goerigk	Germany	4:51.68
16	2	1	Lea Polonsky	Israel	4:53.35
17	2	0	Ambre Franquinet	Belgium	4:55.74
18	2	9	Ieva Maļuka	Latvia	4:59.02
	1	0	Réka Nyirádi	Hungary	Did not start

The final was held at 19:28.^[4]

Rank	Lane	Name	Nationality	Time	Notes
	4	Viktória Mihályvári-Farkas	Hungary	4:37.56
	5	Zsuzsanna Jakabos	Hungary	4:39.79
	2	Freya Colbert	Great Britain	4:40.06
4	6	Sara Franceschi	Italy	4:40.91
5	7	Alba Vázquez	Spain	4:42.40
6	3	Ilaria Cusinato	Italy	4:44.24
7	1	Katie Shanahan	Great Britain	4:49.38
7	8	Zoe Vogelmann	Germany	4:49.38