Sperm-associated antigen 5

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.^[5][6]

SPAG5
Identifiers
Aliases	SPAG5, DEEPEST, MAP126, hMAP126, Sperm associated antigen 5
External IDs	OMIM: 615562; MGI: 1927470; HomoloGene: 4718; GeneCards: SPAG5; OMA:SPAG5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,577,565 bp[1] End 28,599,025 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,192,355 bp[2] End 78,213,283 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ventricular zone gonad ganglionic eminence mucosa of transverse colon testicle right lobe of liver right lobe of thyroid gland human kidney Top expressed in epithelium of lens spermatocyte ventricular zone spermatid tail of embryo lumbar subsegment of spinal cord seminiferous tubule epiblast genital tubercle mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding Cellular component spindle mitotic spindle chromosome microtubule organizing center centriolar satellite spindle pole chromosome, centromeric region microtubule plus-end midbody microtubule kinetochore cytoskeleton cytoplasm mitotic spindle pole spindle microtubule Biological process mitotic sister chromatid segregation cell cycle spindle organization cell division protein localization to centrosome chromosome segregation regulation of attachment of spindle microtubules to kinetochore positive regulation of intracellular transport regulation of metaphase plate congression positive regulation of spindle assembly establishment of spindle orientation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10615 54141 Ensembl ENSG00000076382 ENSMUSG00000002055 UniProt Q96R06 Q7TME2 RefSeq (mRNA) NM_006461 NM_017407 RefSeq (protein) NP_006452 NP_059103 Location (UCSC) Chr 17: 28.58 – 28.6 Mb Chr 11: 78.19 – 78.21 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.^[6]