San Ignacio (the Spanish language name of St. Ignatius) is a common toponym in parts of the world where that language is or was spoken:
Argentina
- San Ignacio, Argentina, Misiones Province
- San Ignacio Miní, a Jesuit mission in Misiones Province
Belize
- San Ignacio, Belize (Cayo District), towns in western Belize
Bolivia
Chile
- San Ignacio, Chile, a town in the Ñuble Region
Costa Rica
- San Ignacio District, Acosta, San José Province
El Salvador
Honduras
Mexico
- San Ignacio, Baja California Sur
- San Ignacio, Chihuahua (Práxedis G. Guerrero)
- San Ignacio, Sinaloa
- San Ignacio Río Muerto (Sonora)
- San Ignacio Lagoon
- San Ignacio Cerro Gordo, Jalisco
Northern Mariana Islands
- Former colonial name of Pagan
Paraguay
- San Ignacio, Paraguay, a city and district in the Misiones Department
Peru
- San Ignacio, Perú
- San Ignacio District, Peru
- San Ignacio Province, Cajamarca Region