SUV39H1

SUV39H1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTS
Identifiers
Aliases	SUV39H1, H3-K9-HMTase 1, KMT1A, MG44, SUV39H, suppressor of variegation 3-9 homolog 1, SUV39H1 histone lysine methyltransferase
External IDs	OMIM: 300254; MGI: 1099440; HomoloGene: 2388; GeneCards: SUV39H1; OMA:SUV39H1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	48,709,016 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,940,999 bp
RNA expression pattern
	Top expressed in
	gonad; ; granulocyte; ; ventricular zone; ; apex of heart; ; mucosa of transverse colon; ; testicle; ; epithelium of esophagus; ; tibialis anterior muscle; ; ganglionic eminence; ; gastrocnemius muscle;
	Top expressed in
	abdominal wall; ; fetal liver hematopoietic progenitor cell; ; yolk sac; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; thymus; ; epiblast; ; tail of embryo; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity; histone methyltransferase activity (H3-K9 specific); S-adenosylmethionine-dependent methyltransferase activity; protein N-terminus binding; zinc ion binding; chromatin binding; transcription cis-regulatory region binding; metal ion binding; protein binding; histone-lysine N-methyltransferase activity;
Cellular component	nuclear lamina; nucleoplasm; chromosome; heterochromatin; condensed nuclear chromosome; rDNA heterochromatin; chromatin silencing complex; chromosome, centromeric region; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; histone H3-K9 dimethylation; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; histone H3-K9 trimethylation; cellular response to DNA damage stimulus; methylation; rDNA heterochromatin assembly; rRNA processing; histone lysine methylation; cell cycle; viral process; negative regulation of transcription, DNA-templated; cellular response to hypoxia; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	6839
	20937
	ENSG00000101945
	ENSMUSG00000039231
	O43463
	O54864
	NM_003173; NM_001282166
	NM_001290716; NM_011514; NM_001358237
	NP_001269095; NP_003164
	NP_001277645; NP_035644; NP_001345166
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.^[5]

Function

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating lysine-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.^[6]In mouse embryonic stem cells, Suv39h1 expression is repressed by OCT4 protein through the induction of an antisense long non-coding RNA.^[7]

Interactions

SUV39H1 has been shown to interact with:

PIN1^[17]

Search

SUV39H1

Contents

Function

Interactions

References

Further reading