SLC20A2

SLC20A2
Identifiers
Aliases	SLC20A2, GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1, solute carrier family 20 member 2, IBGC2
External IDs	OMIM: 158378; MGI: 97851; HomoloGene: 68531; GeneCards: SLC20A2; OMA:SLC20A2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,541,926 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,059,628 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; popliteal artery; ; muscle of thigh; ; tibial arteries; ; right auricle; ; vena cava; ; corpus callosum; ; olfactory zone of nasal mucosa; ; C1 segment;
	Top expressed in
	molar; ; interventricular septum; ; extraocular muscle; ; masseter muscle; ; retinal pigment epithelium; ; lens; ; iris; ; myocardium of ventricle; ; muscle of thigh; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium:phosphate symporter activity; symporter activity; virus receptor activity; inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	sodium ion transport; viral entry into host cell; phosphate ion transport; viral process; ion transport; sodium ion transmembrane transport; transmembrane transport; phosphate ion transmembrane transport; sodium-dependent phosphate transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6575
	20516
	ENSG00000168575
	ENSMUSG00000037656
	Q08357
	Q80UP8
	NM_001257180; NM_001257181; NM_006749
	NM_011394
	NP_001244109; NP_001244110; NP_006740
	NP_035524
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.^[5]^[6]^[7]

Genomics

This gene is found on the short arm of chromosome 8 (8p12-p11) on the minus (Crick) strand. It is 123,077 bases in length. The encoded protein has 652 amino acids and the predicted molecular weight of the protein is 70.392 kilodaltons.

Function

The protein acts as a homodimer and is involved in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.

Clinical significance

Mutations in the SLC20A2 gene are associated with idiopathic basal ganglia calcification (Fahr's syndrome). This association suggests that familial idiopathic basal ganglia calcification is caused by changes in phosphate homeostasis, since this gene encodes for PIT-2, an inorganic phosphate transporter.^[8]

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SLC20A2

Contents

Genomics

Function

Clinical significance

See also

References

Further reading