Reference ranges for blood tests
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the area of pathology that is generally concerned with analysis of bodily fluids.[citation needed]
Blood test results should always be interpreted using the reference range provided by the laboratory that performed the test.[1]
Interpretation
A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval).[2] It is determined by collecting data from vast numbers of laboratory tests.[citation needed]
Plasma or whole blood
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible. The precise factor depends on hematocrit as well as amount inside RBCs. Exceptions are mainly those values that denote total blood concentration, and in this article they are:[3]
- All values in Hematology – red blood cells (except hemoglobin in plasma)
- All values in Hematology – white blood cells
- Platelet count (Plt)
A few values are for inside red blood cells only:
- Vitamin B9 (folic acid/folate) in red blood cells
- Mean corpuscular hemoglobin concentration (MCHC)
Units
- Mass concentration (g/dL or g/L) is the most common measurement unit in the United States. Is usually given with dL (decilitres) as the denominator in the United States, and usually with L (litres) in, for example, Sweden.[citation needed]
- Molar concentration (mol/L) is used to a higher degree in most of the rest of the world, including the United Kingdom and other parts of Europe and Australia and New Zealand.[4]
- International units (IU) are based on measured biological activity or effect, or for some substances, a specified equivalent mass.[citation needed]
- Enzyme activity (kat) is commonly used for e.g. liver function tests like AST, ALT, LD and γ-GT in Sweden.[5]
- Percentages and time-dependent units (mol/s) are used for calculated derived parameters, e.g. for beta cell function in homeostasis model assessment or thyroid's secretory capacity.[citation needed]
Arterial or venous
If not otherwise specified, a reference range for a blood test is generally the venous range, as the standard process of obtaining a sample is by venipuncture. An exception is for acid–base and blood gases, which are generally given for arterial blood.[citation needed]
Still, the blood values are approximately equal between the arterial and venous sides for most substances, with the exception of acid–base, blood gases and drugs (used in therapeutic drug monitoring (TDM) assays).[6] Arterial levels for drugs are generally higher than venous levels because of extraction while passing through tissues.[6]
Usual or optimal
Reference ranges are usually given as what are the usual (or normal) values found in the population, more specifically the prediction interval that 95% of the population fall into. This may also be called standard range. In contrast, optimal (health) range or therapeutic target is a reference range or limit that is based on concentrations or levels that are associated with optimal health or minimal risk of related complications and diseases. For most substances presented, the optimal levels are the ones normally found in the population as well. More specifically, optimal levels are generally close to a central tendency of the values found in the population. However, usual and optimal levels may differ substantially, most notably among vitamins and blood lipids, so these tables give limits on both standard and optimal (or target) ranges. In addition, some values, including troponin I and brain natriuretic peptide, are given as the estimated appropriate cutoffs to distinguish healthy people from people with specific conditions, which here are myocardial infarction and congestive heart failure, respectively, for the aforementioned substances.[7][8][9]
Variability
References range may vary with age, sex, race, pregnancy,[10] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy, lack of standardisation, lack of certified reference material and differing antibody reactivity.[11] Also, reference ranges may be inaccurate when the reference groups used to establish the ranges are small.[12]
Sorted by concentration
By mass and molarity
Smaller, narrower boxes indicate a more tight homeostatic regulation when measured as standard "usual" reference range.
Hormones predominate at the left part of the scale, shown with a red at ng/L or pmol/L, being in very low concentration. There appears to be the greatest cluster of substances in the yellow part (μg/L or nmol/L), becoming sparser in the green part (mg/L or μmol/L). However, there is another cluster containing many metabolic substances like cholesterol and glucose at the limit with the blue part (g/L or mmol/L).[citation needed]
The unit conversions of substance concentrations from the molar to the mass concentration scale above are made as follows:
- Numerically:
- Measured directly in distance on the scales:
,
where distance is the direct (not logarithmic) distance in number of decades or "octaves" to the right the mass concentration is found. To translate from mass to molar concentration, the dividend (molar mass and the divisor (1000) in the division change places, or, alternatively, distance to right is changed to distance to left. Substances with a molar mass around 1000g/mol (e.g. thyroxine) are almost vertically aligned in the mass and molar images. Adrenocorticotropic hormone, on the other hand, with a molar mass of 4540,[13] is 0.7 decades to the right in the mass image. Substances with molar mass below 1000g/mol (e.g. electrolytes and metabolites) would have "negative" distance, that is, masses deviating to the left.Many substances given in mass concentration are not given in molar amount because they haven't been added to the article.
The diagram above can also be used as an alternative way to convert any substance concentration (not only the normal or optimal ones) from molar to mass units and vice versa for those substances appearing in both scales, by measuring how much they are horizontally displaced from one another (representing the molar mass for that substance), and using the same distance from the concentration to be converted to determine the equivalent concentration in terms of the other unit. For example, on a certain monitor, the horizontal distance between the upper limits for parathyroid hormone in pmol/L and pg/mL may be 7 cm, with the mass concentration to the right. A molar concentration of, for example, 5 pmol/L would therefore correspond to a mass concentration located 7 cm to the right in the mass diagram, that is, approximately 45 pg/mL.
By units
Units do not necessarily imply anything about molarity or mass.
A few substances are below this main interval, e.g. thyroid stimulating hormone, being measured in mU/L, or above, like rheumatoid factor and CA19-9, being measured in U/mL.
By enzyme activity
White blood cells
Sorted by category
Ions and trace metals
Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper.
| Test | Lower limit | Upper limit | Unit* | Comments |
|---|---|---|---|---|
| Sodium (Na) | 135,[14] 137[5][15] | 145,[5][15] 147[14] | mmol/L or mEq/L[14] | See hyponatremia or hypernatremia |
| 310,[16] 320[16] | 330,[16] 340[16] | mg/dL | ||
| Potassium (K) | 3.5,[5][14] 3.6[15] | 5.0,[5][14][15] 5.1 | mmol/L or mEq/L[14] | See hypokalemia or hyperkalemia |
| 14[17] | 20[17] | mg/dL | ||
| Chloride (Cl) | 95,[14] 98,[18] 100[5] | 105,[14] 106,[18] 110[5] | mmol/L or mEq/L[14] | See hypochloremia or hyperchloremia |
| 340[19] | 370[19] | mg/dL | ||
| Ionized calcium (Ca) | 1.03,[20] 1.10[5] | 1.23,[20] 1.30[5] | mmol/L | See hypocalcaemia or hypercalcaemia |
| 4.1,[21] 4.4[21] | 4.9,[21] 5.2[21] | mg/dL | ||
| Total calcium (Ca) | 2.1,[14][22] 2.2[5] | 2.5,[5][22] 2.6,[22] 2.8[14] | mmol/L | |
| 8.4,[14] 8.5[23] | 10.2,[14] 10.5[23] | mg/dL | ||
| Total serum iron (TSI) – male | 65,[24] 76[15] | 176,[24] 198[15] | μg/dL | See hypoferremia or the following: iron overload (hemochromatosis), iron poisoning, siderosis, hemosiderosis, hyperferremia |
| 11.6,[25][26] 13.6[26] | 30,[25] 32,[26] 35[26] | μmol/L | ||
| Total serum iron (TSI) – female | 26,[15] 50[24] | 170[15][24] | μg/dL | |
| 4.6,[26] 8.9[25] | 30.4[25] | μmol/L | ||
| Total serum iron (TSI) – newborns | 100[24] | 250[24] | μg/dL | |
| 18[26] | 45[26] | μmol/L | ||
| Total serum iron (TSI) – children | 50[24] | 120[24] | μg/dL | |
| 9[26] | 21[26] | μmol/L | ||
| Total iron-binding capacity (TIBC) | 240,[24] 262[15] | 450,[24] 474[15] | μg/dL | |
| 43,[26] 47[26] | 81,[26] 85[26] | μmol/L | ||
| Transferrin | 190,[27] 194,[5] 204[15] | 326,[5] 330,[27] 360[15] | mg/dL | |
| 25[28] | 45[28] | μmol/L | ||
| Transferrin saturation | 20[24] | 50[24] | % | |
| Ferritin – Males and postmenopausal females | 12[29] | 300[29][30] | ng/mL or μg/L | |
| 27[31] | 670[31] | pmol/L | ||
| Ferritin – premenopausal females | 12[29] | 150[29] – 200[30] | ng/mL or μg/L | |
| 27[31] | 330[31] – 440[31] | pmol/L | ||
| Ammonia | 10,[32] 20[33] | 35,[32] 65[33] | μmol/L | See hypoammonemia and hyperammonemia |
| 17,[34] 34[34] | 60,[34] 110[34] | μg/dL | ||
| Copper (Cu) | 70[23] | 150[23] | μg/dL | See hypocupremia or hypercupremia |
| 11[35][36] | 24[35] | μmol/L | ||
| Ceruloplasmin | 15[23] | 60[23] | mg/dL | |
| 1[37] | 4[37] | μmol/L | ||
| Phosphate (HPO42−) | 0.8 | 1.5[38] | mmol/L | See hypophosphatemia or hyperphosphatemia |
| Inorganic phosphorus (serum) | 1.0[14] | 1.5[14] | mmol/L | |
| 3.0[14] | 4.5[14] | mg/dL | ||
| Zinc (Zn) | 60,[39] 72[40] | 110,[40] 130[39] | μg/dL | See zinc deficiency or zinc poisoning |
| 9.2,[41] 11[5] | 17,[5] 20[41] | μmol/L | ||
| Magnesium | 1.5,[23] 1.7[42] | 2.0,[23] 2.3[42] | mEq/L or mg/dL | See hypomagnesemia or hypermagnesemia |
| 0.6,[43] 0.7[5] | 0.82,[43] 0.95[5] | mmol/L |
- Note: Although 'mEq' for mass and 'mEq/L' are sometimes used in the United States and elsewhere, they are not part of SI and are now considered redundant.
Acid–base and blood gases
If arterial/venous is not specified for an acid–base or blood gas value, then it generally refers to arterial, and not venous which otherwise is standard for other blood tests.[citation needed]
Acid–base and blood gases are among the few blood constituents that exhibit substantial difference between arterial and venous values.[6] Still, pH, bicarbonate and base excess show a high level of inter-method reliability between arterial and venous tests, so arterial and venous values are roughly equivalent for these.[44]
| Test | Arterial/Venous | Lower limit | Upper limit | Unit |
|---|---|---|---|---|
| pH | Arterial | 7.34,[15] 7.35[14] | 7.44,[15] 7.45[14] | |
| Venous | 7.31[45] | 7.41[45] | ||
| [H+] | Arterial | 36[14] | 44[14] | nmol/L |
| 3.6[46] | 4.4[46] | ng/dL | ||
| Base excess | Arterial & venous[45] | −3[45] | +3[45] | mEq/L |
| Oxygen partial pressure (pO2) | Arterial pO2 | 10,[14] 11[47] | 13,[47] 14[14] | kPa |
| 75,[14][15] 83[23] | 100,[15] 105[14] | mmHg or torr | ||
| Venous | 4.0[47] | 5.3[47] | kPa | |
| 30[45] | 40[45] | mmHg or torr | ||
| Oxygen saturation | Arterial | 94,[45] 95,[18] 96[23] | 100[18][23] | % |
| Venous | Approximately 75[18] | |||
| Carbon dioxide partial pressure (pCO2) | Arterial PaCO2 | 4.4,[14] 4.7[47] | 5.9,[14] 6.0[47] | kPa |
| 33,[14] 35[15] | 44,[14] 45[15] | mmHg or torr | ||
| Venous | 5.5,[47] | 6.8[47] | kPa | |
| 41[45] | 51[45] | mmHg or torr | ||
| Absolute content of carbon dioxide (CO2) | Arterial | 23[45] | 30[45] | mmol/L |
| 100[48] | 132[48] | mg/dL | ||
| Bicarbonate (HCO3−) | Arterial & venous | 18[23] | 23[23] | mmol/L |
| 110[49] | 140[49] | mg/dL | ||
| Standard bicarbonate (SBCe) | Arterial & venous | 21, 22[14] | 27, 28[14] | mmol/L or mEq/L[14] |
| 134[49] | 170[49] | mg/dL | ||
Liver function
| Test | Patient type | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|---|
| Total protein (TotPro) | 60,[14] 63[15] | 78,[14] 82,[15] 84[23] | g/L | See serum total protein Interpretation | |
| Albumin | 35[14][50] | 48,[15] 55[14] | g/L | See hypoalbuminemia | |
| 3.5[15] | 4.8,[15] 5.5[14] | U/L | |||
| 540[51] | 740[51] | μmol/L | |||
| Globulins | 23[14] | 35[14] | g/L | ||
| Total bilirubin | 1.7,[52] 2,[14] 3.4,[52] 5[5] | 17,[14][52] 22,[52] 25[5] | μmol/L | ||
| 0.1,[14] 0.2,[15] 0.29[53] | 1.0,[14][23] 1.3,[15] 1.4[53] | mg/dL | |||
| Direct/conjugated bilirubin | 0.0[14] or N/A[5] | 5,[14] 7[5][52] | μmol/L | ||
| 0[14][15] | 0.3,[14][15] 0.4[23] | mg/dL | |||
| Alanine transaminase (ALT/ALAT[5]) | 5,[54] 7,[15] 8[14] | 20,[14] 21,[18] 56[15] | U/L | Also called serum glutamic pyruvic transaminase (SGPT) | |
| Female | 0.15[5] | 0.75[5] | μkat/L | ||
| Male | 0.15[5] | 1.1[5] | |||
| Aspartate transaminase (AST/ASAT[5]) | Female | 6[55] | 34[55] | IU/L | Also called serum glutamic oxaloacetic transaminase (SGOT) |
| 0.25[5] | 0.60[5] | μkat/L | |||
| Male | 8[55] | 40[55] | IU/L | ||
| 0.25[5] | 0.75[5] | μkat/L | |||
| Alkaline phosphatase (ALP) | 0.6[5] | 1.8[5] | μkat/L | ||
| Female | 42[54] | 98[54] | U/L | ||
| Male | 53[54] | 128[54] | |||
| Gamma glutamyl transferase (GGT) | 5,[54] 8[15] | 40,[54] 78[15] | U/L | ||
| Female | 0.63[56] | μkat/L | |||
| Male | 0.92[56] | μkat/L |
Cardiac tests
| Test | Patient type | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|---|
| Creatine kinase (CK) | Male | 24,[57] 38,[15] 60[54] | 174,[23] 320[54] | U/L or ng/mL | |
| 0.42[58] | 1.5[58] | μkat/L | |||
| Female | 24,[57] 38,[15] 96[23] | 140,[23] 200[54] | U/L or ng/mL | ||
| 0.17[58] | 1.17[58] | μkat/L | |||
| CK-MB | 0 | 3,[15] 3.8,[5] 5[54] | ng/mL or μg/L[5] | ||
| Myoglobin | Female | 1[59] | 66[59] | ng/mL or μg/L | |
| Male | 17[59] | 106[59] | |||
| Cardiac troponin T (low sensitive) | 0.1[7] | ng/mL | 99th percentile cutoff | ||
| Cardiac troponin I (high sensitive) | 0.03[7] | ng/mL | 99th percentile cutoff | ||
| Cardiac troponin T (high sensitive) | Male | 0.022[7] | ng/mL | 99th percentile cutoff | |
| Female | 0.014[7] | ng/mL | 99th percentile cutoff | ||
| newborn/infants | not established | more than adults [60][61] |
| Brain natriuretic peptide (BNP) | |
| Interpretation | Range / Cutoff |
|---|---|
| Congestive heart failure unlikely | < 100 pg/mL[8][9] |
| "Gray zone" | 100–500 pg/mL[8][9] |
| Congestive heart failure likely | > 500 pg/mL[8][9] |
| NT-proBNP | ||
| Interpretation | Age | Cutoff |
|---|---|---|
| Congestive heart failure likely | < 75 years | > 125 pg/mL[62] |
| > 75 years | > 450pg/mL[62] | |
Lipids
| Test | Patient type | Lower limit | Upper limit | Unit | Therapeutic target |
|---|---|---|---|---|---|
| Triglycerides | 10–39 years | 54[23] | 110[23] | mg/dL | < 100 mg/dL[63] or 1.1 mmol/L[63] |
| 0.61[64] | 1.2[64] | mmol/L | |||
| 40–59 years | 70[23] | 150[23] | mg/dL | ||
| 0.77[64] | 1.7[64] | mmol/L | |||
| > 60 years | 80[23] | 150[23] | mg/dL | ||
| 0.9[64] | 1.7[64] | mmol/L | |||
| Total cholesterol | 3.0,[65] 3.6[14][65] | 5.0,[5][66] 6.5[14] | mmol/L | < 3.9 mmol/L[63] | |
| 120,[15] 140[14] | 200,[15] 250[14] | mg/dL | < 150 mg/dL[63] | ||
| HDL cholesterol | Female | 1.0,[67] 1.2,[5] 1.3[65] | 2.2[67] | mmol/L | > 1.0[67] or 1.6[65] mmol/L 40[68] or 60[69] mg/dL |
| 40,[68] 50[70] | 86[68] | mg/dL | |||
| HDL cholesterol | Male | 0.9[5][67] | 2.0[67] | mmol/L | |
| 35[68] | 80[68] | mg/dL | |||
| LDL cholesterol (Not valid when triglycerides >5.0 mmol/L) | 2.0,[67] 2.4[66] | 3.0,[5][66] 3.4[67] | mmol/L | < 2.5 mmol/L[67] | |
| 80,[68] 94[68] | 120,[68] 130[68] | mg/dL | < 100 mg/dL[68] | ||
| LDL/HDL quotient | n/a | 5[5] | (unitless) |
Tumour markers
| Test | Patient type | Cutoff | Unit | Comments |
|---|---|---|---|---|
| Alpha fetoprotein (AFP) | 44[15] | ng/mL or μg/L | Hepatocellular carcinoma or testicular cancer | |
| Beta human chorionic gonadotrophin (β-hCG) | In males and non-pregnant females | 5[15] | IU/L or mU/mL | choriocarcinoma |
| CA19-9 | 40[15] | U/mL | Pancreatic cancer | |
| CA-125 | 30,[71] 35[72] | kU/L or U/mL | ||
| Carcinoembryonic antigen (CEA) | Non-smokers, 50 years | 3.4,[5] 3.6[73] | μg/L | |
| Non-smokers, 70 years | 4.1[73] | |||
| Smokers | 5[74] | |||
| Prostate specific antigen (PSA) | 40–49 years | 1.2–2.9[75] | μg/L[5][15] or ng/mL[23] | More detailed cutoffs in PSA – Serum levels |
| 70–79 years, non-African-American | 4.0–9.0[75] | |||
| 70–79 years, African-American | 7.7–13[75] | |||
| PAP | 3[23] | units/dL (Bodansky units) | ||
| Calcitonin | 5,[76] 15[76] | ng/L or pg/mL | Cutoff against medullary thyroid cancer[76] More detailed cutoffs in Calcitonin article |
Endocrinology
Thyroid hormones
| Test | Patient type | Lower limit | Upper limit | Unit |
|---|---|---|---|---|
| Thyroid stimulating hormone (TSH or thyrotropin) | Adults – standard range | 0.3,[5] 0.4,[15] 0.5,[23] 0.6[77] | 4.0,[5] 4.5,[15] 6.0[23] | mIU/L or μIU/mL |
| Adults – optimal range | 0.3,[78] 0.5[79] | 2.0,[79] 3.0[78] | ||
| Infants | 1.3[80] | 19[80] | ||
| Free thyroxine (FT4) | Normal adult | 0.7,[81] 0.8[15] | 1.4,[81] 1.5,[15] 1.8[82] | ng/dL |
| 9,[5][83] 10,[84] 12[85] | 18,[5][83] 23[85] | pmol/L | ||
| Child/Adolescent 31 d – 18 y | 0.8[81] | 2.0[81] | ng/dL | |
| 10[83] | 26[83] | pmol/L | ||
| Pregnant | 0.5[81] | 1.0[81] | ng/dL | |
| 6.5[83] | 13[83] | pmol/L | ||
| Total thyroxine | 4,[84] 5.5[15] | 11,[84] 12.3[15] | μg/dL | |
| 60[84][85] | 140,[84] 160[85] | nmol/L | ||
| Free triiodothyronine (FT3) | Normal adult | 0.2[84] | 0.5[84] | ng/dL |
| 3.1[86] | 7.7[86] | pmol/L | ||
| Children 2-16 y | 0.1[87] | 0.6[87] | ng/dL | |
| 1.5[86] | 9.2[86] | pmol/L | ||
| Total triiodothyronine | 60,[15] 75[84] | 175,[84] 181[15] | ng/dL | |
| 0.9,[5] 1.1[84] | 2.5,[5] 2.7[84] | nmol/L | ||
| Thyroxine-binding globulin (TBG) | 12[15] | 30[15] | mg/L | |
| Thyroglobulin (Tg) | 1.5[84] | 30[84] | pmol/L | |
| 1[84] | 20[84] | μg/L |
Sex hormones
The diagrams below take inter-cycle and inter-woman variability into account in displaying reference ranges for estradiol, progesterone, FSH and LH.
| Test | Patient type | Lower limit | Upper limit | Unit |
|---|---|---|---|---|
| Dihydrotestosterone | adult male | 30 | 85 | ng/dL |
| Testosterone | Male, overall | 8,[89] 10[90] | 27,[89] 35[90] | nmol/L |
| 230,[91] 300[92] | 780–1000[91][92] | ng/dL | ||
| Male < 50 years | 10[5] | 45[5] | nmol/L | |
| 290[91] | 1300[91] | ng/dL | ||
| Male > 50 years | 6.2[5] | 26[5] | nmol/L | |
| 180[91] | 740[91] | ng/dL | ||
| Female | 0.7[90] | 2.8–3.0[90][5] | nmol/L | |
| 20[92] | 80–85[92][91] | ng/dL | ||
| 17α-Hydroxyprogesterone | male | 0.06[23] | 3.0[23] | mg/L |
| 0.18[93] | 9.1[93] | μmol/L | ||
| Female (Follicular phase) | 0.2[23] | 1.0[23] | mg/L | |
| 0.6[93] | 3.0[93] | μmol/L | ||
| Follicle-stimulating hormone (FSH) | Prepubertal | <1[94] | 3[94] | IU/L |
| Adult male | 1[94] | 8[94] | ||
| Adult female (follicular and luteal phase) | 1[94] | 11[94] | ||
| Adult female (Ovulation) | 6[94] 95% PI (standard) | 26[94] 95% PI) | ||
| 5[95] 90% PI (used in diagram) | 15[95] (90% PI) | |||
| Post-menopausal female | 30[94] | 118[94] | ||
| Luteinizing hormone (LH) | Female, peak | 20[95] 90% PI (used in diagram) | 75[95] (90% PI) | IU/L |
| Female, post-menopausal | 15[96] | 60[96] | ||
| Male aged 18+ | 2[97] | 9[97] | ||
| Estradiol (an estrogen) | Adult male | 50[98] | 200[98] | pmol/L |
| 14[99] | 55[99] | pg/mL | ||
| Adult female (day 5 of follicular phase, and luteal phase) | 70[98] | 500,[98] 600[98] | pmol/L | |
| 19[99] | 140,[99] 160[99] | pg/mL | ||
| Adult female – free (not protein bound) | 0.5[100] | 9[100] | pg/mL | |
| 1.7[100] | 33[100] | pmol/L | ||
| Post-menopausal female | N/A[98] | < 130[98] | pmol/L | |
| N/A[99] | < 35[99] | pg/mL | ||
| Progesterone | Female in mid-luteal phase (day 21–23) | 17,[95] 35[101] | 92[101] | nmol/L |
| 6,[95] 11[102] | 29[102] | ng/mL | ||
| Androstenedione | Adult male and female | 60[96] | 270[96] | ng/dL |
| Post-menopausal female | < 180[96] | |||
| Prepubertal | < 60[96] | |||
| Dehydroepiandrosterone sulfate | Adult male and female | 30[103] | 400[103] | μg/dL |
| SHBG | Adult female | 40[104] | 120[104] | nmol/L |
| Adult male | 20[104] | 60[104] | ||
| Anti-Müllerian hormone (AMH) | 13–45 years | 0.7[105] | 20[105] | ng/mL |
| 5[106] | 140[106] | pmol/L |
Other hormones
Vitamins
Also including the vitamin B12)-related amino acid homocysteine.
| Test | Patient type | Standard range | Optimal range | Unit | ||
|---|---|---|---|---|---|---|
| Lower limit | Upper limit | Lower limit | Upper limit | |||
| Vitamin A | 30[23] | 65[23] | μg/dL | |||
| Vitamin B9 (Folic acid/Folate) – Serum | Age > 1 year | 3.0[126] | 16[126] | 5[127] | ng/mL or μg/L | |
| 6.8[128] | 36[128] | 11[128] | nmol/L | |||
| Vitamin B9 (Folic acid/Folate) – Red blood cells | 200[126] | 600[126] | ng/mL or μg/L | |||
| 450[128] | 1400[128] | nmol/L | ||||
| Pregnant | 400[126] | ng/mL or μg/L | ||||
| 900[126] | nmol/L | |||||
| Vitamin B12 (Cobalamin) | 130,[129] 160[130] | 700,[129] 950[130] | ng/L | |||
| 100,[131] 120[5] | 520,[131] 700[5] | pmol/L | ||||
| Homocysteine | 3.3,[132] 5.9[132] | 7.2,[132] 15.3[132] | 6.3[63] | μmol/L | ||
| 45,[133] 80[133] | 100,[133] 210[133] | 85[63] | μg/dL | |||
| Vitamin C (Ascorbic acid) | 0.4[23] | 1.5[23] | 0.9[63] | mg/dL | ||
| 23[134] | 85[134] | 50[63] | μmol/L | |||
| 25-hydroxycholecalciferol (a vitamin D) | 8,[23][115] 9[115] | 40,[115] 80[23] | 30,[118] 40[119] | 65,[119] 100[118] | ng/mL | |
| 20,[116] 23[117] | 95,[117] 150[116] | 85,[63] 100[119] | 120,[63] 160[119] | nmol/L | ||
| Vitamin E | 28[63] | μmol/L | ||||
| 1.2[63] | mg/dL | |||||
Toxic Substances
| Test | Limit type | Limit | Unit |
|---|---|---|---|
| Lead | Optimal health range | < 20[18] or 40[23] | μg/dL |
| Blood ethanol content | Limit for drunk driving | 0,[135] 0.2,[135] 0.8[135] | ‰ or g/L |
| 17.4[136] | mmol/L |
Hematology
Red blood cells
These values (except Hemoglobin in plasma) are for total blood and not only blood plasma.
| Test | Patient | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|---|
| Hemoglobin (Hb) | Male | 2.0,[137] 2.1[14][138] | 2.5,[137] 2.7[14][138] | mmol/L | Higher in neonates, lower in children. |
| 130,[5] 132,[15] 135[14] | 162,[15] 170,[5] 175[14] | g/L | |||
| Female | 1.8,[137] 1.9[14][138] | 2.3,[137] 2.5[14][137][138] | mmol/L | Sex difference negligible until adulthood. | |
| 120[5][14][15] | 150,[5] 152,[15] 160[14][23] | g/L | |||
| Hemoglobin subunits (sometimes displayed simply as "Hemoglobin") | Male | 8.0,[139] 8.4[139] | 10.0,[139] 10.8[139] | mmol/L | 4 per hemoglobin molecule |
| Female | 7.2,[139] 7.6[139] | 9.2,[139] 10.0[139] | |||
| Hemoglobin in plasma | 0.16[14] | 0.62[14] | μmol/L | Normally diminutive compared with inside red blood cells | |
| 1 | 4 | mg/dL | |||
| Glycated hemoglobin (HbA1c) | < 50 years | 3.6[5] | 5.0[5] | % of Hb | |
| > 50 years | 3.9[5] | 5.3[5] | |||
| Haptoglobin | < 50 years | 0.35[5] | 1.9[5] | g/L | |
| > 50 years | 0.47[5] | 2.1[5] | |||
| Hematocrit (Hct) | Male | 0.39,[5] 0.4,[15] 0.41,[14] 0.45[23] | 0.50,[5] 0.52,[15] 0.53,[14] 0.62[23] | L/L | |
| Female | 0.35,[5] 0.36,[14] 0.37[15][23] | 0.46,[5][14][15] 0.48[23] | L/L | ||
| Child | 0.31[15] | 0.43[15] | L/L | ||
| Mean corpuscular volume (MCV) | Male | 76,[23] 82[15] | 100,[23] 102[15] | fL | Cells are larger in neonates, though smaller in other children. |
| Female | 78[15] | 101[15] | fL | ||
| Red blood cell distribution width (RDW) | 11.5[15] | 14.5[15] | % | ||
| Mean cell hemoglobin (MCH) | 0.39[14] | 0.54[14] | fmol/cell | ||
| 25,[14] 27[5][23] | 32,[23] 33,[5] 35[14] | pg/cell | |||
| Mean corpuscular hemoglobin concentration (MCHC) | 4.8,[140] 5.0[140] | 5.4,[140] 5.6[140] | mmol/L | ||
| 31,[15] 32[5][23] | 35,[15] 36[5][23] | g/dL or %[note 1] | |||
| Erythrocytes/Red blood cells (RBC) | Male | 4.2,[23] 4.3[5][14][15] | 5.7,[5] 5.9,[14] 6.2,[15] 6.9[23] | x1012/L or million/mm3 | |
| Female | 3.5,[14] 3.8,[15] 3.9[5] | 5.1,[5] 5.5[14][15] | |||
| Infant/Child | 3.8[15] | 5.5[15] | |||
| Reticulocytes | Adult | 26[5] | 130[5] | x109/L | |
| 0.5[14][15] | 1.5[14][15] | % of RBC | |||
| Newborn | 1.1[15] | 4.5[15] | % of RBC | ||
| Infant | 0.5[15] | 3.1[15] | % of RBC | ||
| Immature reticulocyte fraction (IRF) | Adult | 1.6[141] | 12.1[141] | % of reticulocytes | |
| Reticulocyte hemoglobin equivalent | Adult | 30.0[141] | 37.6[141] | % | |
| 24.1[142] | 35.8[142] | pg | |||
| Immature platelet fraction (IPF) | Adult | 0.8[141] | 5.6[141] | % |
White blood cells
These values are for total blood and not only blood plasma.
| Test | Patient type | Lower limit | Upper limit | Unit |
|---|---|---|---|---|
| White Blood Cell Count (WBC) | Adult | 3.5,[5] 3.9,[143] 4.1,[15] 4.5[14] | 9.0,[5] 10.0,[143] 10.9,[15] 11[14] |
|
| Newborn | 9[144] | 30[144] | ||
| 1 year old | 6[144] | 18[144] | ||
| Neutrophil granulocytes (A.K.A. grans, polys, PMNs, or segs) | Adult | 1.3,[5] 1.8,[143] 2[144] | 5.4,[5] 7,[143] 8[144] | x109/L |
| 45–54[14] | 62,[14] 74 | % of WBC | ||
| Newborn | 6[144] | 26[144] | x109/L | |
| Neutrophilic band forms | Adult | 0.7[144] | x109/L | |
| 3[14] | 5[14] | % of WBC | ||
| Lymphocytes | Adult | 0.7,[5] 1.0[143][144] | 3.5,[143] 3.9,[5] 4.8[144] | x109/L |
| 16–25[14] | 33,[14] 45 | % of WBC | ||
| Newborn | 2[144] | 11[144] | x109/L | |
| Monocytes | Adult | 0.1,[5] 0.2[145][146] | 0.8[5][144][146] | x109/L |
| 3,[14] 4.0 | 7,[14] 10 | % of WBC | ||
| Newborn | 0.4[144] | 3.1[144] | x109/L | |
| Mononuclear leukocytes (Lymphocytes + monocytes) | Adult | 1.5 | 5 | x109/L |
| 20 | 35 | % of WBC | ||
| CD4+ T cells | Adult | 0.4,[15] 0.5[18] | 1.5,[18] 1.8[15] | x109/L |
| Eosinophil granulocytes | Adult | 0.0,[5] 0.04[146] | 0.44,[146] 0.45,[144] 0.5[5] | x109/L |
| 1[14] | 3,[14] 7 | % of WBC | ||
| Newborn | 0.02[144] | 0.85[144] | x109/L | |
| Basophil granulocytes | Adult | 40[143] | 100,[5][146] 200,[144] 900[143] | x106/L |
| 0.0 | 0.75,[14] 2 | % of WBC | ||
| Newborn | 0.64[144] | x109/L |
Coagulation
| Test | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|
| Thrombocyte/Platelet count (Plt) | 140,[15] 150[5][14] | 350,[5][23] 400,[14] 450[15] | x109/L or x1000/μL | |
| Mean platelet volume (MPV) | 7.2,[147] 7.4,[148] 7.5[149] | 10.4,[148] 11.5,[149] 11.7[147] | fL | |
| Prothrombin time (PT) | 10,[18] 11,[14][150] 12[15] | 13,[18] 13.5,[150] 14,[15] 15[14] | s | PT reference varies between laboratory kits – INR is standardised |
| INR | 0.9[5] | 1.2[5] | The INR is a corrected ratio of a patient's PT to normal | |
| Activated partial thromboplastin time (APTT) | 18,[15] 30[5][18] | 28,[15] 42,[5] 45[18] | s | |
| Thrombin clotting time (TCT) | 11 | 18 | s | |
| Fibrinogen | 1.7,[15] 2.0[5] | 3.6,[5] 4.2[15] | g/L | |
| Antithrombin | 0.80[5] | 1.2[5] | kIU/L | |
| 0.15,[151] 0.17[152] | 0.2,[151] 0.39[152] | mg/mL | ||
| Bleeding time | 2 | 9 | minutes | |
| Viscosity | 1.5[153] | 1.72[153] | cP |
Immunology
Acute phase proteins
Acute phase proteins are markers of inflammation.
| Test | Patient | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|---|
| Erythrocyte sedimentation rate (ESR) | Male | 0 | Age÷2[154] | mm/h | ESR increases with age and tends to be higher in females.[155] |
| Female | (Age+10)÷2[154] | ||||
| C-reactive protein (CRP) | 5,[5][156] 6[157] | mg/L | |||
| 200,[158] 240[158] | nmol/L | ||||
| Alpha 1-antitrypsin (AAT) | 20,[159] 22[160] | 38,[160] 53[159] | μmol/L | ||
| 89,[161] 97[5] | 170,[5] 230[161] | mg/dL | |||
| Procalcitonin | 0.15[162] | ng/mL or μg/L |
Isotypes of antibodies
| Test | Patient | Lower limit | Upper limit | Unit |
|---|---|---|---|---|
| IgA | Adult | 70,[5] 110[163] | 360,[5] 560[163] | mg/dL |
| IgD | 0.5[163] | 3.0[163] | ||
| IgE | 0.01[163] | 0.04[163] | ||
| IgG | 800[163] | 1800[163] | ||
| IgM | 54[163] | 220[163] |
Autoantibodies
Autoantibodies are usually absent or very low, so instead of being given in standard reference ranges, the values usually denote where they are said to be present, or whether the test is a positive test. There may also be an equivocal interval, where it is uncertain whether there is a significantly increased level.
| Test | Negative | Equivocal | Positive | Unit |
|---|---|---|---|---|
| anti-SS-A (Ro) | < 1.0[164] | n/a | ≥ 1.0[164] | Units (U) |
| anti-SS-B (La) | < 1.0[165] | n/a | ≥ 1.0[165] | |
| Anti ds-DNA | < 30.0[166] | 30.0–75.0[166] | > 75.0[166] | International Units per millilitre (IU/mL) |
| Anti ss-DNA | < 8[167] | 8–10[167] | > 10[167] | Units per millilitre (U/mL) |
| Anti-histone antibodies | < 25[167] | n/a[167] | > 25[167] | |
| Cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) | < 20[167] | 21–30[167] | > 30[167] | |
| Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) | < 5[167] | n/a | > 5[167] | |
| Anti-mitochondrial antibodies (AMA) | < 0.1[168] | 0.1-0.9[168] | ≥ 1.0[168] | Units (U) |
| Rheumatoid factor (RF) | < 20 | 20–30 | > 30[15] | Units per millilitre (U/mL) |
| Antistreptolysin O titre (ASOT) in preschoolers | > 100 | |||
| ASOT at school age | > 250[15] | |||
| ASOT in adults | > 125[15] |
| Test | Negative | Low/weak positive | Moderate positive | High/strong positive | Unit |
|---|---|---|---|---|---|
| Anti-phospholipid IgG | < 20[167] | 20–30[167] | 31–50[167] | > 51[167] | GPLU/mL[167] |
| Anti-phospholipid IgM | < 1.5[167] | 1.5–2.5[167] | 2–9.9[167] | > 10[167] | MPL /mL[167] |
| Anti-phospholipid IgA | < 10[167] | 10–20[167] | 21–30[167] | > 31[167] | arb U/mL[167] |
| Anti-citrullinated protein antibodies | < 20[167] | 20–39[167] | 40–59[167] | > 60[167] | EU[167] |
Other immunology
| Test | Lower limit | Upper limit | Unit |
|---|---|---|---|
| Serum free light chains (FLC): kappa/lambda ratio | 0.26[169] | 1.65[169] | (unitless) |
Other enzymes and proteins
| Test | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|
| Serum total protein | 60,[14] 63[15] | 78,[14] 82,[15] 84[23] | g/L | |
| Lactate dehydrogenase (LDH) | 50[23] | 150[23] | U/L | |
| 0.4[54] | 1.7[54] | μmol/L | ||
| 1.8[5] | 3.4[5] | μkat/L | < 70 years old[5] | |
| Amylase | 25,[14] 30,[15] 53[23] | 110,[15] 120,[170] 123,[23] 125,[14] 190[54] | U/L | |
| 0.15[5] | 1.1[5] | μkat/L | ||
| 200[158] | 240[158] | nmol/L | ||
| D-dimer | n/a | 500[171] | ng/mL | Higher in pregnant women[172] |
| 0.5[5] | mg/L | |||
| Lipase | 7,[15] 10,[23] 23[54] | 60,[15] 150,[23] 208[54] | U/L | |
| Angiotensin-converting enzyme (ACE) | 23[54] | 57[54] | U/L | |
| Acid phosphatase | 3.0[54] | ng/mL | ||
| Eosinophil cationic protein (ECP) | 2.3[5] | 16[5] | μg/L |
Other electrolytes and metabolites
Electrolytes and metabolites:For iron and copper, some related proteins are also included.
| Test | Patient type | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|---|
| Osmolality | 275,[14] 280,[23] 281[5] | 295,[14] 296,[23] 297[5] | mOsm/kg | Plasma weight excludes solutes | |
| Osmolarity | Slightly less than osmolality | mOsm/L | Plasma volume includes solutes | ||
| Urea | 3.0[173] | 7.0[173] | mmol/L | BUN – blood urea nitrogen | |
| 7[14] | 18,[14] 21[15] | mg/dL | |||
| * Uric acid[15] | 0.18[14] | 0.48[14] | mmol/L | ||
| Female | 2.0[23] | 7.0[23] | mg/dL | ||
| Male | 2.1[23] | 8.5[23] | mg/dL | ||
| Creatinine | Male | 60,[5] 68[174] | 90,[5] 118[174] | μmol/L | May be complemented with creatinine clearance |
| 0.7,[175] 0.8[175] | 1.0,[175] 1.3[175] | mg/dL | |||
| Female | 50,[5] 68[174] | 90,[5] 98[174] | μmol/L | ||
| 0.6,[175] 0.8[175] | 1.0,[175] 1.1[175] | mg/dL | |||
| BUN/Creatinine Ratio | 5[23] | 35[23] | – | ||
| Plasma glucose (fasting) | 3.8,[14] 4.0[5] | 6.0,[5] 6.1[176] | mmol/L | See also glycated hemoglobin (in hematology) | |
| 65,[15] 70,[14] 72[177] | 100,[176] 110[23] | mg/dL | |||
| Full blood glucose (fasting) | 3.3[5] | 5.6[5] | mmol/L | ||
| 60[177] | 100[177] | mg/dL | |||
| Random glucose | 3.9[178] | 7.8[178] | mmol/L | ||
| 70[179] | 140[179] | mg/dL | |||
| Lactate (Venous) | 4.5[23] | 19.8[23] | mg/dL | ||
| 0.5[180] | 2.2[180] | mmol/L | |||
| Lactate (Arterial) | 4.5[23] | 14.4[23] | mg/dL | ||
| 0.5[180] | 1.6[180] | mmol/L | |||
| Pyruvate | 300[23] | 900[23] | μg/dL | ||
| 34[181] | 102[181] | μmol/L | |||
| Ketones | 1[182] | mg/dL | |||
| 0.1[182] | mmol/L | ||||
Medication
| Test | Lower limit | Upper limit | Unit | Comments |
|---|---|---|---|---|
| Digoxin | 0.5[183] | 2.0[183] | ng/mL | Narrow therapeutic window |
| 0.6[183] | 2.6[183] | nmol/L | ||
| Lithium | 0.4,[184] 0.5,[185][186] 0.8[187] | 1.3[185][186] | mmol/L | Narrow therapeutic window |
| Paracetamol | 30[188] | mg/L | Risk of paracetamol toxicity at higher levels | |
| 200[188] | μmol/L |
See also
Notes
References
External links
Further reading
- Rappoport, n.; Paik, P.; Oskotsky, B.; Tor, R.; Ziv, E.; Zaitlen, N.; Butte, A. (4 November 2017). "Creating ethnicity-specific reference intervals for lab tests from EHR data". bioRxiv 10.1101/213892.