Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.[1]
| Combination of | |
|---|---|
| Oxycodone | Opioid analgesic |
| Acetaminophen | Anilide analgesic |
| Clinical data | |
| Trade names | Percocet, others |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
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| Identifiers | |
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| CompTox Dashboard (EPA) | |
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In 2021, it was the 75th most commonly prescribed medication in the United States, with more than 8 million prescriptions.[2][3]
History
The United States Food and Drug Administration (FDA) first approved Percocet in 1976, under application ANDA 085106.[4]
Society and culture
Implicated in deaths
In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[5] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.[6]
In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.[7][8][9]
In March 2017, US President Donald Trump initiated the Opioid and Drug Abuse Commission.[10] In July 2017, a draft report was published.[11]
