Patrick S. Moore (born October 21, 1956) is an American virologist and epidemiologist who co-discovered together with his wife, Yuan Chang, two different human viruses causing the AIDS-related cancer Kaposi's sarcoma and the skin cancer Merkel cell carcinoma. Moore and Chang have discovered two of the seven known human viruses causing cancer. The couple met while in medical school together and were married in 1989 while they pursued fellowships at different universities.
Patrick Moore | |
|---|---|
 Moore in 2017 | |
| Born | October 21, 1956 Seattle, Washington, U.S. |
| Nationality | American |
| Education | Westminster College Stanford University University of Utah University of California, Berkeley |
| Known for | Discovery of the human cancer viruses KSHV and MCV |
| Spouse | Yuan Chang |
| Awards | Meyenburg Prize (1997) Robert Koch Prize (1998) Charles S. Mott Prize (2003) Passano Award (2017) Paul Ehrlich and Ludwig Darmstaedter Prize (2017) Clarivate Citation Laureates (2017) |
| Scientific career | |
| Fields | Cancer, Microbiology, Epidemiology |
| Institutions | UPMC Hillman Cancer CenterUniversity of Pittsburgh |
Education and career
Moore received a Bachelor of Science in chemistry and biology from Westminster College in Salt Lake City, an M.S. degree from Stanford University, and M.D. and MPhil degrees from the University of Utah, and an M.P.H. degree from the University of California, Berkeley. As an epidemiologist working at the US Centers for Disease Control and Prevention (CDC), he developed widely used international guidelines to control meningococcal meningitis epidemics[1][2] and led a team of CDC epidemiologists during the 1992 Somali Civil War. Civilian death rates documented during this civil war-famine were among the highest ever reported.[3][4] The extreme mortality statistics helped to solidify international support behind the US-led military intervention Operation Restore Hope.[5] He received the 1989 CDC Langmuir Prize for his work on epidemic meningitis control.
After leaving the CDC, Moore served briefly as a New York City epidemiologist but quit to search for new human viruses with his wife, Yuan Chang who was then a newly appointed assistant professor at Columbia University.[6] Unemployed, he worked in his wife's laboratory, allowing him to rapidly pick up training in molecular biology. Despite having no research funding, Moore and Chang used a new molecular biology technique, representational difference analysis, to search for a virus causing Kaposi's sarcoma, the most common malignancy among AIDS patients.[7] In 1994, they discovered a new human herpesvirus, KSHV, in a KS tumor and along with several collaborators showed that it was the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease.[8][9][10] Moore was hired onto the faculty at Columbia and the Chang-Moore Laboratory secured research funding to investigate this new virus. They subsequently sequenced KSHV,[11] identified oncogenes encoded by the virus,[12] demonstrated transmission during transplantation and developed diagnostic tests to detect infection.[13][14] In 2002, he moved his laboratory to the University of Pittsburgh where he served as founding director of the Cancer Virology Program at the UPMC Hillman Cancer Centerr until 2018. Chang and Moore jointly developed a new technique to find human tumor viruses called digital transcriptome subtraction (DTS).[15] Using this approach, they identified the most recently discovered cancer virus, a new human polyomavirus infecting Merkel carcinoma cells in 2008.[16] This virus causes of 50-80% of Merkel cell carcinomas[17] and hence is named Merkel cell polyomavirus. His laboratory currently seeks to understand the role of tumor virus immunoevasion of the innate immune system as a cause for viral tumorigenesis.[18][19][20][21] They have also discovered another polyomavirus (Human polyomavirus 7) as a cause of skin disease in transplant patients,[22] the generation of viral circular RNAs in KSHV, EBV and MCV,[23] the role of CDK1 in controlling protein translation during mitosis[24] and they defined the clonal mutation pattern of Merkel cell polyomavirus in cancers[25] as well as its oncogenes.[26]
Awards
- Moore and Chang are American Cancer Society Research Professors and have been awarded the 1997 Meyenburg Cancer Research Prize, 1998 Robert Koch Prize, the 2003 General Motors Cancer Research Foundation Charles S. Mott Prize,[27] the 2017 Paul Ehrlich and Ludwig Darmstaedter Prize and the 2017 Passano Foundation Passano Award. They are 2017 Clarivate Citation Laureates.
References
Further reading
- Schmidt C (April 2008). "Yuan Chang and Patrick Moore: teaming up to hunt down cancer-causing viruses". Journal of the National Cancer Institute. 100 (8): 524–5, 529. doi:10.1093/jnci/djn122. PMID 18398088.
- Chang Y, Cesarman E, Pessin MS, et al. (December 1994). "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma". Science. 266 (5192): 1865–9. Bibcode:1994Sci...266.1865C. doi:10.1126/science.7997879. PMID 7997879. S2CID 29977325.
- Moore PS, Chang Y (May 1995). "Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection". The New England Journal of Medicine. 332 (18): 1181–5. doi:10.1056/NEJM199505043321801. PMID 7700310.
- Moore PS, Marfin AA, Quenemoen LE, et al. (April 1993). "Mortality rates in displaced and resident populations of central Somalia during 1992 famine". Lancet. 341 (8850): 935–8. doi:10.1016/0140-6736(93)91223-9. PMID 8096276. S2CID 38013442.
- Russo JJ, Bohenzky RA, Chien MC, et al. (December 1996). "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)". Proceedings of the National Academy of Sciences of the United States of America. 93 (25): 14862–7. Bibcode:1996PNAS...9314862R. doi:10.1073/pnas.93.25.14862. PMC 26227. PMID 8962146.
- Moore PS, Broome CV (November 1994). "Cerebrospinal meningitis epidemics". Scientific American. 271 (5): 38–45. Bibcode:1994SciAm.271e..38M. doi:10.1038/scientificamerican1194-38. PMID 7997865.