Osteoglycin

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.^[5]

OGN
Identifiers
Aliases	OGN, OG, OIF, SLRR3A, osteoglycin
External IDs	OMIM: 602383; MGI: 109278; HomoloGene: 8542; GeneCards: OGN; OMA:OGN - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 92,383,268 bp[1] End 92,404,696 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 49,761,522 bp[2] End 49,777,977 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery Descending thoracic aorta parietal pleura ascending aorta gallbladder decidua left coronary artery tendon of biceps brachii cartilage tissue vena cava Top expressed in tunica media of zone of aorta sciatic nerve calvaria epithelium of lens ciliary body cervix left lung carotid body efferent ductule external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding growth factor activity extracellular matrix structural constituent conferring compression resistance Cellular component extracellular vesicle extracellular matrix lysosomal lumen Golgi lumen extracellular exosome extracellular space extracellular region collagen-containing extracellular matrix Biological process negative regulation of smooth muscle cell proliferation axonogenesis keratan sulfate catabolic process keratan sulfate biosynthetic process regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4969 18295 Ensembl ENSG00000106809 ENSMUSG00000021390 UniProt P20774 Q62000 RefSeq (mRNA) NM_033014 NM_014057 NM_024416 NM_008760 RefSeq (protein) NP_054776 NP_077727 NP_148935 NP_054776.1 NP_148935.1 NP_032786 Location (UCSC) Chr 9: 92.38 – 92.4 Mb Chr 13: 49.76 – 49.78 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan^[6] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.^[5]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.^[7][8]