ORC4

ORC4
Identifiers
Aliases	ORC4, ORC4L, ORC4P, origin recognition complex subunit 4
External IDs	OMIM: 603056; MGI: 1347043; HomoloGene: 8059; GeneCards: ORC4; OMA:ORC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	148,021,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	48,840,289 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; islet of Langerhans; ; ganglionic eminence; ; kidney tubule; ; bronchial epithelial cell; ; corpus callosum; ; endothelial cell; ; ventricular zone; ; right uterine tube;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; spermatocyte; ; tail of embryo; ; ventricular zone; ; neural layer of retina; ; embryo; ; epiblast; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; DNA replication origin binding; protein binding; ATP binding;
Cellular component	nuclear origin of replication recognition complex; nucleolus; origin recognition complex; nucleus; nucleoplasm; cytosol;
Biological process	G1 phase; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5000
	26428
	ENSG00000115947
	ENSMUSG00000026761
	O43929
	O88708
NM_001190879; NM_001190881; NM_001190882; NM_002552; NM_181741;
	NM_181742; NM_001374270; NM_001374272
	NM_001177313; NM_011958; NM_001355296
NP_001177808; NP_001177810; NP_001177811; NP_002543; NP_859525;
	NP_859526; NP_001361199; NP_001361201
	NP_001170784; NP_036088; NP_001342225
	Wikidata
View/Edit Human	View/Edit Mouse

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.^[5]^[6]^[7]

Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.^[7]

Interactions

ORC4 has been shown to interact with:

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ORC4

Contents

Function

Interactions

References

Further reading