ORC3

ORC3
Identifiers
Aliases	ORC3, LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDs	OMIM: 604972; MGI: 1354944; HomoloGene: 8225; GeneCards: ORC3; OMA:ORC3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,667,453 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,614,944 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; Achilles tendon; ; ventricular zone; ; glutes; ; gonad; ; embryo; ; ganglionic eminence; ; testicle; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	genital tubercle; ; tail of embryo; ; spermatocyte; ; epiblast; ; zygote; ; ventricular zone; ; maxillary prominence; ; neural layer of retina; ; mandibular prominence; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA replication origin binding; protein binding;
Cellular component	nuclear origin of replication recognition complex; origin recognition complex; nucleus; nucleoplasm; nuclear pre-replicative complex; DNA replication preinitiation complex; nuclear body;
Biological process	G1 phase; DNA replication; neural precursor cell proliferation; DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	23595
	50793
	ENSG00000135336
	ENSMUSG00000040044
	Q9UBD5
	Q9JK30
	NM_001197259; NM_012381; NM_181837
	NM_001159563; NM_015824
	NP_001184188; NP_036513; NP_862820
	NP_001153035; NP_056639
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex (ORC) subunit 3 N-terminus
Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
Symbol	ORC3_N
Pfam	PF07034
InterPro	IPR010748
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.^[5]^[6]^[7]

Function

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[7]

Interactions

ORC3 has been shown to interact with:

MCM4,^[8]
MCM7,^[8]
ORC2,^[6]^[8]^[9]^[10]^[11]
ORC4,^[6]^[9]^[11]
ORC5,^[6]^[8]^[9]^[11] and
ORC6.^[8]^[11]

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ORC3

Contents

Function

Interactions

References

Further reading