Nuclear receptor coactivator 2

NCOA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23, 2FAI, 2G44, 2G5O, 2P15, 2P1T, 2P1U, 2P1V, 2Q7J, 2Q7L, 2ZXZ, 2ZY0, 3A9E, 3DZU, 3DZY, 3E00, 3E7C, 3E94, 3FUG, 3GN8, 3K23, 3KWY, 3KYT, 3L0E, 3L0L, 3O1D, 3O1E, 3OAP, 3OZJ, 3PCU, 3PLZ, 3Q95, 3Q97, 3R5M, 3UP0, 3UP3, 4DOS, 4E2J, 4FHH, 4FHI, 4IA1, 4IA2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 2LDC, 2YJD, 3CLD, 3ERD, 3K22, 4CSJ, 4K4J, 4K6I, 4M8E, 4M8H, 4NIE, 4NQA, 4OC7, 4P6W, 4P6X, 4POH, 4POJ, 4PP3, 4PP5, 4PP6, 4PPP, 4PPS, 4PXM, 4Q0A, 4WG0, 4QE6, 4QE8, 4RFW, 4RMC, 4RMD, 4RME, 4ZN9, 4ZO1, 4RUO, 5APJ, 4UDD, 4PLD, 4PLE, 4UDC, 5APH, 5DMC, 5DKB, 5DMF, 4ZNV, 5DVS, 5DL4, 5E0W, 5E19, 4ZUC, 5DI7, 5I4V, 5E0X, 5E1C, 4ZWK, 5DYD, 5DIG, 5DKG, 5DTV, 5EC9, 5DX3, 5DRM, 5BP6, 5DYB, 5DLR, 5E14, 5DXK, 5DUH, 5DVV, 5DU5, 5DXP, 5DP0, 4ZNS, 5DZ3, 5DXR, 5DXQ, 5DZI, 4ZNT, 4ZNW, 5DID, 5DXM, 5EHJ, 5BQ4, 5DY8, 4ZSH, 5DXB, 5DUG, 5DK9, 5EIT, 5BPR, 5DWJ, 5DWI, 5HYR, 5DKS, 4ZUB, 5EI1, 5DZ0, 4ZNU, 4ZNH, 5E15, 4ZN7, 5DZ1, 5DUE, 4ZWH, 5EGV, 5BNU, 5DIE, 5DKE, 5DWG, 5DZH, 5DRJ, 5DWE
Identifiers
Aliases	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2
External IDs	OMIM: 601993; MGI: 1276533; HomoloGene: 4768; GeneCards: NCOA2; OMA:NCOA2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	70,403,808 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	13,374,083 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; endothelial cell; ; secondary oocyte; ; seminal vesicula; ; jejunal mucosa; ; amniotic fluid; ; tibia; ; Epithelium of choroid plexus; ; buccal mucosa cell; ; oral cavity;
	Top expressed in
	substantia nigra; ; lacrimal gland; ; ciliary body; ; left lung lobe; ; retinal pigment epithelium; ; lateral geniculate nucleus; ; habenula; ; median eminence; ; lobe of cerebellum; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; transcription coactivator activity; transcription factor binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nuclear receptor coactivator activity; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; signaling receptor binding; nuclear receptor binding; aryl hydrocarbon receptor binding; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleus; nuclear body; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; cellular response to Thyroglobulin triiodothyronine; rhythmic process; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; transcription, DNA-templated; cellular response to hormone stimulus; regulation of glucose metabolic process; circadian rhythm; bile acid and bile salt transport; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; locomotor rhythm; intracellular receptor signaling pathway; regulation of lipid metabolic process; regulation of gene expression; response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	10499
	17978
	ENSG00000140396
	ENSMUSG00000005886
	Q15596
	Q61026
NM_006540; NM_001321703; NM_001321707; NM_001321711; NM_001321712;
	NM_001321713
	NM_001077695; NM_008678; NM_001302702
NP_001308632; NP_001308636; NP_001308640; NP_001308641; NP_001308642;
	NP_006531
	NP_001289631; NP_032704
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.^[5]^[6]

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).^[7]

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

AR,^[8]^[9]^[10]^[11]^[12]
ARNT,^[13]
BRCA1,^[14]^[15]
DDX17,^[16]
DDX5,^[16]
ESR1,^[11]^[16]^[17]^[18]^[19]
NR3C1,^[20]^[21]
PPFIA4,^[22]
PPARG,^[23]
RXRA,^[24]^[25]
SRA1,^[16] and
VDR.^[11]^[17]^[24]^[26]

References

External links

nuclear receptor coactivator 2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NURSA C90
Overview of all the structural information available in the PDB for UniProt: Q15596 (Human Nuclear receptor coactivator 2) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q61026 (Mouse Nuclear receptor coactivator 2) at the PDBe-KB.

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Search

Nuclear receptor coactivator 2

Contents

Function

Interactions

References

Further reading

External links