Natsume (夏目, 夏芽, 棗, なつめ or ナツメ) is a Japanese feminine given name and a surname, and may refer to:
People with the given name
- Natsume (drummer) (夏芽), a Japanese drummer and voice actress
- Natsume Akatsuki (暁 なつめ), a Japanese light novel author and manga writer
- Natsume Mito (三戸 なつめ, born 1990), a Japanese model, singer, and presenter
- Natsume Ono (オノ ナツメ, born 1977), a Japanese manga artist
- Natsume Sano (佐野 夏芽, born 1985), a Japanese gravure idol
People with the surname
- Fusanosuke Natsume (夏目 房之介, born 1950), a Japanese columnist and cartoonist
- Masako Natsume (夏目 雅子, 1957–1985), a Japanese actor
- Nana Natsume (夏目 ナナ, born 1980), a Japanese former adult video (AV) actress
- Rio Natsume (夏目 理緒, born 1985), a Japanese gravure idol
- Shingo Natsume (夏目 真悟, born 1980), a Japanese director
- Suzu Natsume (夏目 鈴, born 1991), a Japanese actress
- Sōseki Natsume (夏目 漱石, 1867–1916), a Japanese novelist of the early years of the 20th century
- Yoshinobu Natsume (夏目 吉信, 1517–1573), Japanese samurai
- Yoshinori Natsume (夏目 義徳, born 1975), Japanese manga artist
- Yuki Natsume (棗 佑喜, born 1988), Japanese footballer
Fictional characters
- Atsuko Natsume is the protagonist of the All Purpose Cultural Cat Girl Nuku Nuku
- Natsume, a Pokémon character renamed Sabrina in the English version
- Natsume Hyūga, a character in the anime/manga series Alice Academy
- Natsume Takashi, the title character in the manga and anime series Natsume's Book of Friends
- Maya Natsume, a character in the anime Tenjho Tenge
- Asako Natsume, a character in the manga My Little Monster (Tonari No Kaibutsu-kun)
- Mio Natsume, a character in the Ressha Sentai ToQger
- Natsume, known as "Coco" in English, a character in Fighting Foodons
- Mai Natsume, a character from the BlazBlue series
- Natsume, a character in the anime Deca-Dence
Companies
- Natsume Atari, formerly Natsume Co., Ltd., a Japanese video game company founded in 1987
- Natsume Inc., an American video game company founded in 1988