NFAM1

NFAM1
Identifiers
Aliases	NFAM1, CNAIP, bK126B4.4, NFAT activating protein with ITAM motif 1
External IDs	OMIM: 608740; MGI: 1921289; HomoloGene: 12528; GeneCards: NFAM1; OMA:NFAM1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,432,403 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,917,507 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; skin of arm; ; pancreatic ductal cell; ; bone marrow cells; ; tendon of biceps brachii; ; spleen; ; buccal mucosa cell; ; appendix;
	Top expressed in
	granulocyte; ; bone marrow; ; lumbar subsegment of spinal cord; ; blood; ; tibiofemoral joint; ; stroma of bone marrow; ; spleen; ; habenula; ; lip; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; azurophil granule membrane;
Biological process	positive regulation of B cell receptor signaling pathway; cell surface receptor signaling pathway; positive regulation of DNA-binding transcription factor activity; intracellular signal transduction; inflammatory response; regulation of B cell differentiation; signal transduction; positive regulation of cytokine production; neutrophil degranulation; B cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	150372
	74039
	ENSG00000235568
	ENSMUSG00000058099
	Q8NET5
	Q8R4V1
	NM_145912; NM_001318323; NM_001371362
	NM_001271411; NM_001271412; NM_001271413; NM_001271414; NM_028728
	NP_001305252; NP_666017; NP_001358291
	NP_001258340; NP_001258341; NP_001258342; NP_001258343; NP_083004
	Wikidata
View/Edit Human	View/Edit Mouse

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene.^[5]

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an Immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

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NFAM1

Function

References

Further reading