Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.[5][6][7]
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[7]
NCOA6 has been shown to interact with:
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Coactivators | |
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Corepressors | |
ATP-dependent remodeling factors |