N-Methylpiperazine is a heterocyclic organic compound.
![]() | |
Names | |
---|---|
Preferred IUPAC name 1-Methylpiperazine | |
Other names
| |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.003.309 |
EC Number |
|
PubChem CID | |
UNII | |
UN number | 2920 |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C5H12N2 | |
Molar mass | 100.165 g·mol−1 |
Melting point | −6 °C (21 °F; 267 K)[1] |
Boiling point | 138 °C (280 °F; 411 K)[1] |
Hazards | |
GHS labelling: | |
![]() ![]() ![]() ![]() | |
Danger | |
H226, H312, H314, H317, H330, H331, H332 | |
P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P272, P280, P284, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P311, P312, P320, P321, P322, P333+P313, P363, P370+P378, P403+P233, P403+P235, P405, P501 | |
NFPA 704 (fire diamond) | |
Safety data sheet (SDS) | FischerSci |
Related compounds | |
Related compounds | Piperazine, 4-methylpyridine |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Uses
N-Methylpiperazine is a common building block used in organic synthesis.[2] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine,[3] meclizine, and sildenafil.
The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes.[4]
Synthesis
Industrially, N-methylpiperazine is produced by reacting diethanolamine and methylamine at 250 bar and 200 °C.[5][6]
References
🔥 Top keywords: Main PageSpecial:SearchPage 3Wikipedia:Featured picturesHouse of the DragonUEFA Euro 2024Bryson DeChambeauJuneteenthInside Out 2Eid al-AdhaCleopatraDeaths in 2024Merrily We Roll Along (musical)Jonathan GroffJude Bellingham.xxx77th Tony AwardsBridgertonGary PlauchéKylian MbappéDaniel RadcliffeUEFA European Championship2024 ICC Men's T20 World CupUnit 731The Boys (TV series)Rory McIlroyN'Golo KantéUEFA Euro 2020YouTubeRomelu LukakuOpinion polling for the 2024 United Kingdom general electionThe Boys season 4Romania national football teamNicola CoughlanStereophonic (play)Gene WilderErin DarkeAntoine GriezmannProject 2025