MCM3

MCM3
Identifiers
Aliases	MCM3, HCC5, P1-P1.h, RLFB, minichromosome maintenance complex component 3
External IDs	OMIM: 602693; MGI: 101845; HomoloGene: 1791; GeneCards: MCM3; OMA:MCM3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,284,881 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,890,536 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; mucosa of transverse colon; ; appendix; ; rectum; ; lymph node; ; gonad; ; trabecular bone; ; body of uterus;
	Top expressed in
	somite; ; epiblast; ; mandibular prominence; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; ventricular zone; ; primitive streak; ; tail of embryo; ; otic placode; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; protein binding; hydrolase activity; ATP binding; DNA replication origin binding; single-stranded DNA binding;
Cellular component	cytoplasm; centrosome; membrane; nucleoplasm; perinuclear region of cytoplasm; alpha DNA polymerase:primase complex; MCM complex; nucleus; nucleolus; intracellular membrane-bounded organelle;
Biological process	G1 phase; DNA replication; DNA replication initiation; cell cycle; G1/S transition of mitotic cell cycle; double-strand break repair via break-induced replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; DNA strand elongation involved in DNA replication; mitotic DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	4172
	17215
	ENSG00000112118
	ENSMUSG00000041859
	P25205; Q7Z6P5
	P25206
	NM_002388; NM_001270472
	NM_008563
NP_001257401; NP_002379; NP_001353298; NP_001353299; NP_001353300;
	NP_001353301; NP_001353302; NP_001353303; NP_001353304
	NP_032589
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.^[5]

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.^[6]

Interactions

MCM3 has been shown to interact with:

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MCM3

Contents

Function

Interactions

See also

References

Further reading