The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.[5] It is localized to 11q13.[5]
This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve,[6] is common in exocrine glands and in the CNS.[7][8]
It is predominantly found bound to G proteins of class Gq[9][10] that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.
Effects
- EPSP in autonomic ganglia[citation needed]
- Secretion from salivary glands
- Gastric acid secretion from stomach[5]
- Via the central nervous system (especially within the brain); mediating certain core aspects of perception, attention, cognitive functioning and likely; memory consolidation.[11][12] This is a notable component in regards to the M1 receptor since it helps explain how pharmacological compounds which antagonize the receptor site can consistently produce mental states like delirium (a major disruption in attention and decrease in baseline-level cognitive functioning), as well as the perceptual alterations and conspicuous hallucinations experienced with deliriant drugs like Datura. As of 2015, the M1 receptor remains the only known muscarinic receptor to have this effect of hallucinogenic delirium when its functionality is inhibited or antagonized.[13]
- Cognitive flexibility
- Synaptic plasticity modulation
- Anxiety-like behavior and spontaneous working memory
- Salivation
- Task switching
- Vagally-induced bronchoconstriction[5]
- Mediating olfactory behaviors and detection of "social odors" which have implications (for rodents) in aggression, mating, and social behavior.[14]
Occurrence in free living amoebae
A structural but not sequential homolog of the human M1 receptor has been reported in Acanthamoeba castellanii[15] and Naegleria fowleri.[16] Antagonists of human M1 receptors (e.g. atropine, diphenhydramine) have been shown to exert anti-proliferative effects on these pathogens.
Mechanism
It couples to Gq, and, to a small extent, Gi and Gs. This results in slow EPSP and decreased K+ conductance.[12][17] It is preassembled to the Gq heterotrimer through a polybasic c-terminal domain.[9]
Ligands
Agonists
- acetylcholine
- carbachol[12]
- cevimeline
- muscarine
- oxotremorine
- pilocarpine[18]
- vedaclidine
- xanomeline
- 77-LH-28-1 - brain penetrant selective M1 allosteric agonist
- CDD-0097
- McN-A-343 - mixed M1/M4 agonist[12]
- L-689, L-660 - mixed M1/M3 agonist
Allosteric modulators
- benzylquinolone carboxylic acid[19]
- BQZ-12[20]
- VU-0090157[21]
- VU-0029767[21]
- VU0467319[22]
- [3H]PT-1284- M1-selective PAM Radioligand[23]
Antagonists
- atropine[12]
- diphenhydramine
- scopolamine[24]
- tramadol[25]
- dicycloverine[12]
- fluoxetine
- hyoscyamine[26]
- ipratropium[12]
- mamba toxin muscarinic toxin 7 (MT7)[12]
- Many antipsychotics like olanzapine, quetiapine, clozapine, chlorpromazine
- pirenzepine
- oxybutynin[12]
- Benzatropine
- telenzepine
- paroxetine
- Tricyclic and tetracyclic antidepressants like clomipramine, imipramine, mirtazapine, amitriptyline
- tolterodine[12]
- Biperiden[27]
See also
References
Further reading
External links
- "Acetylcholine receptors (muscarinic): M1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2 January 2015. Retrieved 25 November 2008.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.