Rank Event Date Firefighter Fatalities Coordinates Reference 1 September 11 attacks September 11, 2001 343 40°42′46.8″N 74°0′48.6″W / 40.713000°N 74.013500°W / 40.713000; -74.013500 [1] 2 Great Fire of 1910 August 22, 1910 78[N 1] 47°25′34″N 116°6′13″W / 47.42611°N 116.10361°W / 47.42611; -116.10361 [1] [3] 3 Texas City disaster April 16, 1947 27 29°22′39″N 94°53′29″W / 29.37750°N 94.89139°W / 29.37750; -94.89139 [4] [2] 4 Chicago Union Stock Yards fire (1910) December 22, 1910 21 41°49′8.31″N 87°39′40.08″W / 41.8189750°N 87.6611333°W / 41.8189750; -87.6611333 [4] [2] 6 McKee refinery fire July 29, 1956 19 35°57′21.28″N 101°53′11.49″W / 35.9559111°N 101.8865250°W / 35.9559111; -101.8865250 [4] [2] Yarnell Hill Fire June 30, 2013 19 34°14′47.84″N 112°45′20.94″W / 34.2466222°N 112.7558167°W / 34.2466222; -112.7558167 [2] 8 Blackwater fire of 1937 August 21, 1937 15 44°24′43″N 109°44′30″W / 44.41194°N 109.74167°W / 44.41194; -109.74167 [5] Rattlesnake Fire July 9, 1953 15 39°39′19.05″N 122°38′9.67″W / 39.6552917°N 122.6360194°W / 39.6552917; -122.6360194 [4] [2] 10 South Canyon Fire July 6, 1994 14 39°34′26.48″N 107°25′36.82″W / 39.5740222°N 107.4268944°W / 39.5740222; -107.4268944 [4] [2] 11 Strand Theatre fire (Brockton, Massachusetts)March 10, 1941 13 42°4′58.40″N 71°1′9.58″W / 42.0828889°N 71.0193278°W / 42.0828889; -71.0193278 [4] [2] Mann Gulch fire August 4, 1949 13 46°52′46.56″N 111°54′17.64″W / 46.8796000°N 111.9049000°W / 46.8796000; -111.9049000 [4] [2] Friedlander Leather Remnants Factory fire December 21, 1910 13 39°58′5.50″N 75°8′29.35″W / 39.9681944°N 75.1414861°W / 39.9681944; -75.1414861 [4] Bowen-Merrill Bookstore Fire March 17, 1890 13 39°46′02.7″N 86°09′32.0″W / 39.767417°N 86.158889°W / 39.767417; -86.158889 [6] 15 Kingman explosion July 5, 1973 12 35°12′54.10″N 114°1′48.95″W / 35.2150278°N 114.0302639°W / 35.2150278; -114.0302639 [4] 23rd Street Fire October 17, 1966 12 40°44′27.39″N 73°59′20.01″W / 40.7409417°N 73.9888917°W / 40.7409417; -73.9888917 [4] Loop Fire Disaster November 1, 1966 12 34°20′05″N 118°23′47″W / 34.33472°N 118.39639°W / 34.33472; -118.39639 [N 2] [7] 18 Inaja Fire November 25, 1956 11 33°5′54″N 116°39′50″W / 33.09833°N 116.66389°W / 33.09833; -116.66389 [8] W. T. Jennings Fire April 25, 1854 11 40°42′44″N 74°00′29″W / 40.71233°N 74.008109°W / 40.71233; -74.008109 [9] [10] 20 West Fertilizer Company explosion April 17, 2013 10 31°48′58″N 97°05′17″W / 31.816°N 97.088°W / 31.816; -97.088 [11] 21 Charleston Sofa Super Store fire June 18, 2007 9 40°44′27.39″N 73°59′20.01″W / 40.7409417°N 73.9888917°W / 40.7409417; -73.9888917 [12] Hotel Vendome fire June 17, 1972 9 42°21′4.55″N 71°4′43.09″W / 42.3512639°N 71.0786361°W / 42.3512639; -71.0786361 [4] [2] Collins Block Fire (Syracuse, New York) February 3, 1939 9 43°3′4.79″N 76°9′12.92″W / 43.0513306°N 76.1535889°W / 43.0513306; -76.1535889 [13] 24 Great Boston Fire of 1872 November 9, 1872 8 42°21′13.75″N 71°3′30.80″W / 42.3538194°N 71.0585556°W / 42.3538194; -71.0585556 [1] 1975 Philadelphia Gulf refinery fire August 17, 1975 8 39°54′7″N 75°12′17″W / 39.90194°N 75.20472°W / 39.90194; -75.20472 [14] Jackson Pyrotechnic Explosion (Chester, Pennsylvania) February 17, 1882 8 39°50′46″N 75°21′24″W / 39.84611°N 75.35667°W / 39.84611; -75.35667 [15] 27 Woolworth Fire- Charleston WV March 4, 1949 7 38°20'.970"N 81°38'.139' W 28 Waldbaum's supermarket fire August 2, 1978 6 40°35′33.93″N 73°57′0.48″W / 40.5927583°N 73.9501333°W / 40.5927583; -73.9501333 [16] 28 Queens soap plant fire October 26, 1962 6 40°43′39″N 73°55′24″W / 40.72740°N 73.92338°W / 40.72740; -73.92338 [17] [18] 28 Kansas City ammonium nitrate explosion November 29, 1988 6 39°50′47.98″N 94°34′22.49″W / 39.8466611°N 94.5729139°W / 39.8466611; -94.5729139 [19] 28 Worcester Cold Storage and Warehouse Co. fire (Worcester, Massachusetts)December 3, 1999 6 42°15′36.23″N 71°47′34.17″W / 42.2600639°N 71.7928250°W / 42.2600639; -71.7928250 [4]