The following highways are numbered 143:
Canada
Costa Rica
Germany
Japan
Japan National Route 143
Fukuoka Prefectural Route 143
Nara Prefectural Route 143
Malaysia
United States
U.S. Highway 143 (former)
Alabama State Route 143
Arizona State Route 143
Arkansas Highway 143
California State Route 143 (unbuilt)
Florida State Road 143
Georgia State Route 143 (former)
Illinois Route 143
Indiana State Road 143
Iowa Highway 143
K-143 (Kansas highway)
Kentucky Route 143
Louisiana Highway 143
Maine State Route 143
Maryland Route 143 (former)
Massachusetts Route 143
M-143 (Michigan highway) (one former and one current highway)
Missouri Route 143
New Jersey Route 143
New Mexico State Road 143
New York State Route 143
North Carolina Highway 143
Ohio State Route 143- Oklahoma State Highway 143 (former)
Pennsylvania Route 143
Tennessee State Route 143
Texas State Highway 143 (former)
Utah State Route 143- Vermont Route 143
Virginia State Route 143- Virginia State Route 143 (1923-1928) (former)
- Virginia State Route 143 (1933-1942) (former)
Washington State Route 143 (two former highways)
Wisconsin Highway 143
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- Territories
| Preceded by 142 | Lists of highways 143 | Succeeded by 144 |