Event | Years | Location | Disease | Death toll (estimate) | Ref. |
---|
1350 BC plague of Megiddo | c. 1350 BC | Megiddo, land of Canaan | Amarna letters EA 244, Biridiya, mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust" | Unknown | [30] |
Hittite Plague/"Hand of Nergal" | c. 1330 BC | Near East, Hittite Empire, Alashiya, possibly Egypt | Unknown, possibly Tularemia. Mentioned in Amarna letter EA 35 as the "Hand of Nergal", cause of death of Šuppiluliuma I. | Unknown | |
Plague of Athens | 430–426 BC | Greece, Libya, Egypt, Ethiopia | Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever | 75,000–100,000 | [31][32][33][34] |
412 BC epidemic | 412 BC | Greece (Northern Greece, Roman Republic) | Unknown, possibly influenza | 473,000 (10% of the Roman Population) | [35] |
Antonine Plague | 165–180 (possibly up to 190) | Roman Empire | Unknown, possibly smallpox | 5–10 million | [36][37] |
Jian'an Plague | 217 | Han dynasty | Unknown, possibly typhoid fever or viral hemorrhagic fever | 2 Million | [38][39] |
Plague of Cyprian | 249–262 | Europe | Unknown, possibly smallpox | 310,000 | [40][41] |
Plague of Justinian (beginning of first plague pandemic) | 541–549 | Europe and West Asia | Bubonic plague | 15–100 million | [6][42][43] |
580 Dysentery Epidemic in Gaul | 580 | Gaul | Dysentery or possibly smallpox | 450,000 (10% of the Gaul population) | [44] |
Roman Plague of 590 (part of first plague pandemic) | 590 | Rome, Byzantine Empire | Bubonic plague | Unknown | [45] |
Plague of Sheroe (part of first plague pandemic) | 627–628 | Bilad al-Sham | Bubonic plague | 25,000+ | |
Plague of Amwas (part of first plague pandemic) | 638–639 | Byzantine Empire, West Asia, Africa | Bubonic plague | 25,000+ | [46] |
Plague of 664 (part of first plague pandemic) | 664–689 | British Isles | Bubonic plague | Unknown | [47] |
Plague of 698–701 (part of first plague pandemic) | 698–701 | Byzantine Empire, West Asia, Syria, Mesopotamia | Bubonic plague | Unknown | [48] |
735–737 Japanese smallpox epidemic | 735–737 | Japan | Smallpox | 2 million (approx. 1⁄3 of Japanese population) | [16][49] |
Plague of 746–747 (part of first plague pandemic) | 746–747 | Byzantine Empire, West Asia, Africa | Bubonic plague | Unknown | [46] |
Black Death (start of the second plague pandemic) | 1346–1353 | Eurasia and North Africa | Bubonic plague | 75–200 million (30–60% of European population and 33% percent of the Middle Eastern population) | [50] |
Sweating sickness (multiple outbreaks) | 1485–1551 | Britain (England) and later continental Europe | Unknown, possibly an unknown species of hantavirus | 10,000+ | [51] |
1489 Spain typhus epidemic | 1489 | Spain | Typhus | 17,000 | [52] |
1510 influenza pandemic | 1510 | Asia, North Africa, Europe | Influenza | Unknown, around 1% of those infected | [53] |
1520 Mexico smallpox epidemic | 1519–1520 | Mexico | Smallpox | 5–8 million (40% of population) | [13] |
Cocoliztli epidemic of 1545–1548 | 1545–1548 | Mexico | Possibly Salmonella enterica | 5–15 million (80% of population) | [54][55][56][57] |
1557 influenza pandemic | 1557–1559 | Asia, Africa, Europe, and Americas | Influenza | 2.5–5 Million (10% of the infected) | |
1561 Chile smallpox epidemic | 1561–1562 | Chile | Smallpox | 120,000–150,000 (20–25% of native population) | [58] |
1563 London plague (part of the second plague pandemic) | 1563–1564 | London, England | Bubonic plague | 20,100+ | [59] |
Cocoliztli epidemic of 1576 | 1576–1580 | Mexico | Possibly Salmonella enterica | 2–2.5 million (50% of population) | [54][55][56][57] |
1582 Tenerife plague epidemic (part of the second plague pandemic) | 1582–1583 | Tenerife, Spain | Bubonic plague | 5,000–9,000 | [60] |
1592–1596 Seneca nation measles epidemic | 1592–1596 | Seneca nation, North America | Measles | Unknown | [61] |
1592–1593 Malta plague epidemic (part of the second plague pandemic) | 1592–1593 | Malta | Bubonic plague | 3,000 | [62] |
1592–1593 London plague (part of the second plague pandemic) | 1592–1593 | London, England | Bubonic plague | 19,900+ | [63] |
1596–1602 Spain plague epidemic (part of the second plague pandemic) | 1596–1602 | Spain | Bubonic plague | 600,000–700,000 | [64] |
1600–1650 South America malaria epidemic | 1600–1650 | South America | Malaria | Unknown | [citation needed] |
1603 London plague (part of the second plague pandemic) | 1603 | London, England | Bubonic plague | 40,000 | [65][66][67] |
1616 New England infections epidemic | 1616–1620 | Southern New England, British North America, especially the Wampanoag people | Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D | 1,143,000–3,429,000 (estimated 30–90% of population) | [68][69] |
1629–1631 Italian plague (part of the second plague pandemic) | 1629–1631 | Italy | Bubonic plague | 1 million | [70] |
1632–1635 Augsburg plague epidemic (part of the second plague pandemic) | 1632–1635 | Augsburg, Germany | Bubonic plague | 13,712 | [71] |
Massachusetts smallpox epidemic | 1633–1634 | Massachusetts Bay Colony, Thirteen Colonies | Smallpox | 1,000 | [72] |
1634–1640 Wyandot people epidemic | 1634–1640 | Wyandot people, North America | Smallpox and Influenza | 15,000–25,000 | [73] |
1637 London plague epidemic (part of the second plague pandemic) | 1636–1637 | London and Westminster, England | Bubonic plague | 10,400 | [74] |
Great Plague in the late Ming dynasty (part of the second plague pandemic) | 1633–1644 | China | Bubonic plague | 200,000+ | [75][76] |
Great Plague of Seville (part of the second plague pandemic) | 1647–1652 | Spain | Bubonic plague | 500,000 | [77] |
1648 Central America yellow fever epidemic | 1648 | Central America | Yellow fever | Unknown | [78] |
Naples Plague (part of the second plague pandemic) | 1656–1658 | Italy | Bubonic plague | 1,250,000 | [79] |
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic) | 1663–1664 | Amsterdam, Netherlands | Bubonic plague | 24,148 | [80] |
Great Plague of London (part of the second plague pandemic) | 1665–1666 | England | Bubonic plague | 100,000 | [81][82] |
1668 France plague (part of the second plague pandemic) | 1668 | France | Bubonic plague | 40,000 | [83] |
1675–1676 Malta plague epidemic (part of the second plague pandemic) | 1675–1676 | Malta | Bubonic plague | 11,300 | [84] |
1676–1685 Spain plague (part of the second plague pandemic) | 1676–1685 | Spain | Bubonic plague | Unknown | [85] |
1677–1678 Boston smallpox epidemic | 1677–1678 | Massachusetts Bay Colony, British North America | Smallpox | 750–1,000 | [86] |
Great Plague of Vienna (part of the second plague pandemic) | 1679 | Vienna, Austria | Bubonic plague | 76,000 | [87] |
1681 Prague plague epidemic (part of the second plague pandemic) | 1681 | Prague, Czech Kingdom | Bubonic plague | 83,000 | [88] |
1687 South Africa influenza outbreak | 1687 | South Africa | Unknown, possibly influenza | Unknown | [89] |
1693 Boston yellow fever epidemic | 1693 | Boston, Massachusetts Bay Colony, British North America | Yellow fever | 3,100+ | [90] |
1699 Charleston and Philadelphia yellow fever epidemic | 1699 | Charleston and Philadelphia, British North America | Yellow fever | 520 (300 in Charleston, 220 in Philadelphia) | [91] |
1702 New York City yellow fever epidemic | 1702 | New York City, British North America | Yellow fever | 500 | [92] |
1702–1703 St. Lawrence Valley smallpox epidemic | 1702–1703 | New France, Canada | Smallpox | 1,300 | [93] |
1707–1708 Iceland smallpox epidemic | 1707–1709 | Iceland | Smallpox | 18,000+ (36% of population) | [94] |
Great Northern War plague outbreak (part of the second plague pandemic) | 1710–1712 | Denmark, Sweden, Lithuania | Bubonic plague | 164,000 | [95][96] |
1713–1715 North America measles epidemic | 1713–1715 | Thirteen Colonies and New France, Canada | Measles | Unknown | [97][98] |
Great Plague of Marseille (part of the second plague pandemic) | 1720–1722 | France | Bubonic plague | 100,000+ | [99] |
1721 Boston smallpox outbreak | 1721–1722 | Massachusetts Bay Colony | Smallpox | 844 | [100] |
1730 Cádiz yellow fever epidemic | 1730 | Cádiz, Spain | Yellow fever | 2,200 | [101] |
1732–1733 Thirteen Colonies influenza epidemic | 1732–1733 | Thirteen Colonies | Influenza | Unknown | [102] |
1733 New France smallpox epidemic | 1733 | New France, Canada | Smallpox | Unknown | [103] |
1735–1741 diphtheria epidemic | 1735–1741 | New England, Province of New York, Province of New Jersey, British North America | Diphtheria | 20,000 | [104] |
Great Plague of 1738 (part of the second plague pandemic) | 1738 | Balkans | Bubonic plague | 50,000 | [105] |
1738–1739 North Carolina smallpox epidemic | 1738–1739 | Province of Carolina, Thirteen Colonies | Smallpox | 7,700–11,700 | [106] |
1741 Cartagena yellow fever epidemic | 1741 | Cartagena, Colombia | Yellow fever | 20,000 | [107] |
1743 Sicily plague epidemic (part of the second plague pandemic) | 1743 | Messina, Sicily, Italy | Bubonic plague | 40,000–50,000 | [108][109] |
1759 North America measles outbreak | 1759 | North America | Measles | Unknown | [110] |
1760 Charleston smallpox epidemic | 1760 | Charleston, British North America | Smallpox | 730–940 | [111][112] |
1762 Havana yellow fever epidemic | 1762 | Havana, Cuba | Yellow fever | 8,000 | [107] |
1763 Pittsburgh area smallpox outbreak | 1763 | North America, present-day Pittsburgh area | Smallpox | Unknown | [113] |
1770–1772 Russian plague (part of the second plague pandemic) | 1770–1772 | Russia | Bubonic plague | 50,000 | [114] |
1772 North America measles epidemic | 1772 | North America | Measles | 1,080 | [115] |
1772–1773 Persian Plague (part of the second plague pandemic) | 1772–1773 | Persia | Bubonic plague | 2 million | [116] |
1775–1776 England influenza outbreak | 1775–1776 | England | Influenza | Unknown | [117] |
1775–1782 North American smallpox epidemic | 1775–1782 | Native populations in what is now the Pacific Northwest of the United States | Smallpox | 11,000+ | [118][119] |
1778 Spain dengue fever outbreak | 1778 | Spain | Dengue fever | Unknown | [120] |
1782 Influenza pandemic | 1782 | Worldwide | Influenza | Unknown | |
1788 Pueblo Indians smallpox epidemic | 1788 | Pueblo Indians in northern New Spain (what is now the Southwestern United States) | Smallpox | Unknown | [121] |
1789–1790 New South Wales smallpox epidemic | 1789–1790 | New South Wales, Australia | Smallpox | 125,251–175,351 (50–70% of native population) | [122][123] |
1793 Philadelphia yellow fever epidemic | 1793 | Philadelphia, United States | Yellow fever | 5,000+ | [124] |
1800–1803 Spain yellow fever epidemic | 1800–1803 | Spain | Yellow fever | 60,000+ | [125] |
1801 Ottoman Empire and Egypt bubonic plague epidemic | 1801 | Ottoman Empire, Egypt | Bubonic plague | Unknown | [126] |
1802–1803 Saint-Domingue yellow fever epidemic | 1802–1803 | Saint-Domingue | Yellow fever | 29,000–55,000 | [127] |
1812 Russia typhus epidemic | 1812 | Russia | Typhus | 300,000 | [52] |
1812–1819 Ottoman plague epidemic (part of the second plague pandemic) | 1812–1819 | Ottoman Empire | Bubonic plague | 300,000+ | [128] |
1813–1814 Malta plague epidemic (part of the second plague pandemic) | 1813–1814 | Malta | Bubonic plague | 4,500 | [129] |
Caragea's plague (part of the second plague pandemic) | 1813 | Romania | Bubonic plague | 60,000 | [130] |
1817–1819 Ireland typhus epidemic | 1817–1819 | Ireland | Typhus | 65,000 | [131] |
First cholera pandemic | 1817–1824 | Asia, Europe | Cholera | 100,000+ | [132] |
1820 Savannah yellow fever epidemic | 1820 | Savannah, Georgia, United States | Yellow fever | 700 | [133] |
1821 Barcelona yellow fever epidemic | 1821 | Barcelona, Spain | Yellow fever | 5,000–20,000 | [134][135] |
Second cholera pandemic | 1826–1837 | Asia, Europe, North America | Cholera | 100,000+ | [136] |
1828–1829 New South Wales smallpox epidemic | 1828–1829 | New South Wales, Australia | Smallpox | 19,000 | [137][138] |
Groningen epidemic | 1829 | Netherlands | Malaria | 2,800 | [139] |
1829–1833 Pacific Northwest malaria epidemic | 1829–1833 | Pacific Northwest, United States | Malaria, possibly other diseases too | 150,000 | [140][141] |
1829–1835 Iran plague outbreak | 1829–1835 | Iran | Bubonic plague | Unknown | [142] |
1834–1836 Egypt plague epidemic | 1834–1836 | Egypt | Bubonic plague | Unknown | [143] |
1837 Great Plains smallpox epidemic | 1837–1838 | Great Plains, United States and Canada | Smallpox | 17,000+ | [144] |
1841 Southern United States yellow fever epidemic | 1841 | Southern United States (especially Louisiana and Florida) | Yellow fever | 3,498 | [145] |
1847 North American typhus epidemic | 1847–1848 | Canada | Typhus | 20,000+ | [146] |
1847 Southern United States yellow fever epidemic | 1847 | Southern United States (especially New Orleans) | Yellow fever | 3,400 | [147] |
1847–1848 influenza epidemic | 1847–1848 | Worldwide | Influenza | Unknown | [148] |
1848–1849 Hawaii epidemic of infections | 1848–1849 | Hawaiian Kingdom | Measles, whooping cough, dysentery and influenza | 10,000 | [149] |
1853 New Orleans yellow fever epidemic | 1853 | New Orleans, United States | Yellow fever | 7,970 | [134] |
Third cholera pandemic | 1846–1860 | Worldwide | Cholera | 1 million+ | [150] |
1853 Ottoman Empire plague epidemic | 1853 | Ottoman Empire | Bubonic plague | Unknown | [151] |
1853 Copenhagen cholera outbreak | 1853 | Copenhagen, Denmark | Cholera | 4,737 | [152] |
1854 Broad Street cholera outbreak | 1854 | London, England | Cholera | 616 | [153] |
1855 Norfolk yellow fever epidemic | 1855 | Norfolk and Portsmouth, England | Yellow fever | 3,000 (2,000 in Norfolk, 1,000 in Portsmouth) | [154] |
Third plague pandemic | 1855–1960 | Worldwide | Bubonic plague | 12–15 million (India and China) | [155][156] |
1855–1857 Montevideo yellow fever epidemic | 1855–1857 | Montevideo, Uruguay | Yellow fever | 3,400 (first wave; 900, second wave; 2,500) | [157] |
1857 Lisbon yellow fever epidemic | 1857 | Lisbon, Portugal | Yellow fever | 6,000 | [134] |
1857 Victoria smallpox epidemic | 1857 | Victoria, Australia | Smallpox | Unknown | [158] |
1857–1859 Europe and the Americas influenza epidemic | 1857–1859 | Europe, North America, South America | Influenza | Unknown | [159] |
1862 Pacific Northwest smallpox epidemic | 1862–1863 | Pacific Northwest, Canada and United States | Smallpox | 20,000+ | [160][161][162] |
1861–1865 United States typhoid fever epidemic | 1861–1865 | United States | Typhoid fever | 80,000 | [163] |
Fourth cholera pandemic | 1863–1875 | Middle East | Cholera | 600,000 | [164] |
1867 Sydney measles epidemic | 1867 | Sydney, Australia | Measles | 748 | [165] |
1871 Buenos Aires yellow fever epidemic | 1871 | Buenos Aires, Argentina | Yellow fever | 13,500–26,200 | [166] |
1870–1875 Europe smallpox epidemic | 1870–1875 | Europe | Smallpox | 500,000 | [167][168] |
1875 Fiji measles outbreak | 1875 | Fiji | Measles | 40,000 | [169] |
1875–1876 Australia scarlet fever epidemic | 1875–1876 | Australia | Scarlet fever | 8,000 | [165] |
1876 Ottoman Empire plague epidemic | 1876 | Ottoman Empire | Bubonic plague | 20,000 | [170] |
1878 New Orleans yellow fever epidemic | 1878 | New Orleans, United States | Yellow fever | 4,046 | [127] |
1878 Mississippi Valley yellow fever epidemic | 1878 | Mississippi Valley, United States | Yellow fever | 13,000 | [127] |
Fifth cholera pandemic | 1881–1896 | Asia, Africa, Europe, South America | Cholera | 298,600 | [171] |
1885 Montreal smallpox epidemic | 1885 | Montreal, Canada | Smallpox | 3,164 | [172] |
1889–1890 pandemic | 1889–1890 | Worldwide | Influenza or Human coronavirus OC43 / HCoV-OC43[18][173] (disputed) | 1 million | [174] |
1894 Hong Kong plague (part of the third plague pandemic) | 1894–1929 | Hong Kong | Bubonic plague | 20,000+ | [175] |
Bombay plague epidemic (part of the third plague pandemic) | 1896–1905 | Bombay, India | Bubonic plague | 20,788 | [176] |
1896–1906 Congo Basin African trypanosomiasis epidemic | 1896–1906 | Congo Basin | African trypanosomiasis | 500,000 | [177] |
1899 Porto plague outbreak (part of the third plague pandemic) | 1899 | Porto, Portugal | Bubonic plague | 132 | [178] |
Sixth cholera pandemic | 1899–1923 | Europe, Asia, Africa | Cholera | 800,000+ | [179] |
San Francisco plague of 1900–1904 (part of the third plague pandemic) | 1900–1904 | San Francisco, United States | Bubonic plague | 119 | [180] |
1900 Sydney bubonic plague epidemic (part of the third plague pandemic) | 1900 | Australia | Bubonic plague | 103 | [181] |
1900–1920 Uganda African trypanosomiasis epidemic | 1900–1920 | Uganda | African trypanosomiasis | 200,000–300,000 | [177] |
Papua New Guinea kuru epidemic | 1901–2009 | Papua New Guinea | Kuru | 2,700–3,000+ | [182][183] |
1903 Fremantle plague epidemic (part of the third plague pandemic) | 1903 | Fremantle, Western Australia | Bubonic plague | 4 | [184] |
1906 malaria outbreak in Ceylon | 1906–1936 | Ceylon | Malaria | 80,000 | [185] |
Manchurian plague (part of the third plague pandemic) | 1910–1911 | China | Pneumonic plague | 60,000 | [186] |
1916 United States polio epidemic | 1916 | United States | Poliomyelitis | 7,130 | [187] |
1918 influenza pandemic ('Spanish flu') | 1918–1920 | Worldwide | Influenza A virus subtype H1N1 | 17–100 million | [188][189][190] |
1918–1922 Russia typhus epidemic | 1918–1922 | Russia | Typhus | 2–3 million | [191] |
1919–1930 encephalitis lethargica epidemic | 1919–1930 | Worldwide | Encephalitis lethargica | 500,000 | [192][193][194] |
1924 Los Angeles pneumonic plague outbreak | 1924 | Los Angeles, United States | Pneumonic plague | 30 | [195] |
1924–1925 Minnesota smallpox epidemic | 1924–1925 | Minnesota, United States | Smallpox | 500 | [196] |
1927 Montreal typhoid fever epidemic | 1927 | Montreal, Canada | Typhoid fever | 538 | [197] |
1929–1930 psittacosis pandemic | 1929–1930 | Worldwide | Psittacosis | 100+ | [198] |
Croydon typhoid outbreak of 1937 | 1937 | Croydon, United Kingdom | Typhoid fever | 43 | [199] |
1937 Australia polio epidemic | 1937 | Australia | Poliomyelitis | Unknown | [200] |
1940 Sudan yellow fever epidemic | 1940 | Sudan | Yellow fever | 1,627 | [201] |
1942–1944 Egypt malaria epidemic | 1942–1944 | Egypt | Malaria | Unknown | [143][202] |
1946 Egypt relapsing fever epidemic | 1946 | Egypt | Relapsing fever | Unknown | [143][202] |
1947 Egypt cholera epidemic | 1947 | Egypt | Cholera | 10,277 | [143][202][203] |
1948–1952 United States polio epidemic | 1948–1952 | United States | Poliomyelitis | 9,000 | [187] |
1957–1958 influenza pandemic ('Asian flu') | 1957–1958 | Worldwide | Influenza A virus subtype H2N2 | 1–4 million | [188][204][205] |
1960–1962 Ethiopia yellow fever epidemic | 1960–1962 | Ethiopia | Yellow fever | 30,000 | [206] |
Seventh cholera pandemic | 1961–present | Worldwide | Cholera (El Tor strain) | 36,000 [citation needed] | [207] |
Hong Kong flu | 1968–1970 | Worldwide | Influenza A virus subtype H3N2 | 1–4 million | [188][204][205] |
1971 Staphorst polio epidemic | 1971 | Staphorst, Netherlands | Poliomyelitis | 5 | [208] |
1972 Yugoslav smallpox outbreak | 1972 | Yugoslavia | Smallpox | 35 | [209] |
London flu | 1972–1973 | United States | Influenza A virus subtype H3N2 | 1,027 | [210] |
1973 Italy cholera epidemic | 1973 | Italy | Cholera (El Tor strain) | 24 | [211] |
1974 smallpox epidemic in India | 1974 | India | Smallpox | 15,000 | [212] |
1977 Russian flu | 1977–1979 | Worldwide | Influenza A virus subtype H1N1 | 700,000 | [213][214] |
Sverdlovsk anthrax leak | 1979 | Russia | Anthrax | 105 | [215] |
HIV/AIDS epidemic | 1981–present | Worldwide | HIV/AIDS | 42 million (as of 2023[update]) | [216] |
1984 Western Sahara plague | 1984 | Western Sahara | Bubonic plague | 64 | [citation needed] |
1986 Oju yellow fever epidemic | 1986 | Oju, Nigeria | Yellow fever | 5,600+ | [217] |
1987 Mali yellow fever epidemic | 1987 | Mali | Yellow fever | 145 | [218] |
1988 Shanghai hepatitis A epidemic | 1988 | Shanghai, China | Hepatitis A | 31–47 | [219][220][221] |
1991 Bangladesh cholera epidemic | 1991 | Bangladesh | Cholera | 8,410–9,432 | [222] |
1991 Latin America cholera epidemic | 1991–1993 | Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala | Cholera | 8,000 | [223][224] |
1994 plague in India | 1994 | India | Bubonic plague and Pneumonic plague | 56 | [225] |
United Kingdom BSE outbreak | 1996–2001 | United Kingdom | Variant Creutzfeldt–Jakob disease / vCJD | 178 | [226][227] |
1996 West Africa meningitis epidemic | 1996 | West Africa | Meningitis | 10,000 | [228] |
1998–1999 Malaysia Nipah virus outbreak | 1998–1999 | Malaysia | Nipah virus infection | 105 | [229] |
1998–2000 Democratic Republic of the Congo Marburg virus outbreak | 1998–2000 | Democratic Republic of the Congo | Marburg virus | 128 | [230] |
2000 Central America dengue epidemic | 2000 | Central America | Dengue fever | 40+ | [231] |
2001 Nigeria cholera epidemic | 2001 | Nigeria | Cholera | 400+ | [232] |
2001 South Africa cholera epidemic | 2001 | South Africa | Cholera | 139 | [233][234] |
2002–2004 SARS outbreak | 2002–2004 | Worldwide | Severe acute respiratory syndrome / SARS | 774 | [235] |
2003–2019 Asia and Egypt avian influenza epidemic | 2003–2019 | China, Southeast Asia and Egypt | Influenza A virus subtype H5N1 | 455 | [236] |
2004 Indonesia dengue epidemic | 2004 | Indonesia | Dengue fever | 658 | [237] |
2004 Sudan Ebola outbreak | 2004 | Sudan | Ebola | 7 | [238] |
2004–2005 Angola Marburg virus outbreak | 2004–2005 | Angola | Marburg virus | 227 | [230] |
2005 dengue outbreak in Singapore | 2005 | Singapore | Dengue fever | 27 | [239] |
2006 Luanda cholera epidemic | 2006 | Luanda, Angola | Cholera | 1,200+ | [240] |
2006 Ituri Province plague epidemic | 2006 | Ituri Province, Democratic Republic of the Congo | Bubonic plague | 61 | [241][242] |
2006 India malaria outbreak | 2006 | India | Malaria | 17 | [243] |
2006 dengue outbreak in India | 2006 | India | Dengue fever | 50+ | [244] |
2006 dengue outbreak in Pakistan | 2006 | Pakistan | Dengue fever | 50+ | [245] |
2006 Philippines dengue epidemic | 2006 | Philippines | Dengue fever | 1,000 | [246] |
2006–2007 East Africa Rift Valley fever outbreak | 2006–2007 | East Africa | Rift Valley fever | 394 | [247] |
Mweka Ebola epidemic | 2007 | Democratic Republic of the Congo | Ebola | 187 | [248] |
2007 Ethiopia cholera epidemic | 2007 | Ethiopia | Cholera | 684 | [249] |
2007 Iraq cholera outbreak | 2007 | Iraq | Cholera | 10 | [250] |
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic | 2007 | Puerto Rico, Dominican Republic, Mexico | Dengue fever | 183 | [251] |
2007 Uganda Ebola outbreak | 2007 | Uganda | Ebola | 37 | [238] |
2007 Netherlands Q-fever epidemic | 2007–2018 | Netherlands | Q-fever | 95 | [252] |
2008 Brazil dengue epidemic | 2008 | Brazil | Dengue fever | 67 | [253] |
2008 Cambodia dengue epidemic | 2008 | Cambodia | Dengue fever | 407 | [254] |
2008 Chad cholera epidemic | 2008 | Chad | Cholera | 123 | [255] |
2008–2017 China hand, foot, and mouth disease epidemic | 2008–2017 | China | Hand, foot, and mouth disease | 3,322+ | [256] |
2008 India cholera epidemic | 2008 | India | Cholera | 115 | [257] |
2008 Madagascar plague outbreak | 2008 | Madagascar | Bubonic plague | 18+ | [258] |
2008 Philippines dengue epidemic | 2008 | Philippines | Dengue fever | 172 | [259] |
2008 Zimbabwean cholera outbreak | 2008–2009 | Zimbabwe | Cholera | 4,293 | [260] |
2009 Bolivian dengue fever epidemic | 2009 | Bolivia | Dengue fever | 18 | [261] |
2009 Gujarat hepatitis outbreak | 2009 | India | Hepatitis B | 49 | [262] |
Queensland 2009 dengue outbreak | 2009 | Queensland, Australia | Dengue fever | 1+ (503 cases) | [263] |
2009–2010 West African meningitis outbreak | 2009–2010 | West Africa | Meningitis | 1,100 | [264] |
2009 swine flu pandemic | 2009–2010 | Worldwide | Influenza A virus subtype H1N1 | Lab confirmed deaths: 18,449 (reported to the WHO) | [265] |
Estimated death toll: 284,000 (possible range 151,700–575,400) | [266] |
2010s Haiti cholera outbreak | 2010–2019 | Haiti | Cholera (strain serogroup O1, serotype Ogawa) | 10,075 | [267] |
2010–2014 Democratic Republic of the Congo measles outbreak | 2010–2014 | Democratic Republic of the Congo | Measles | 4,500+ | [268][269] |
2011 Vietnam hand, foot, and mouth disease epidemic | 2011 | Vietnam | Hand, foot, and mouth disease | 170 | [270][271] |
2011 dengue outbreak in Pakistan | 2011 | Pakistan | Dengue fever | 350+ | [272] |
2012 yellow fever outbreak in Darfur, Sudan | 2012 | Darfur, Sudan | Yellow fever | 171 | [273] |
MERS outbreak | 2012–present | Worldwide | Middle East respiratory syndrome / MERS-CoV | 941 (as of 8 May 2021[update]) | [274][275] |
2013 dengue outbreak in Singapore | 2013 | Singapore | Dengue fever | 8 | |
2013 Vietnam measles outbreak | 2013–2014 | Vietnam | Measles | 142 | [276] |
Western African Ebola virus epidemic | 2013–2016 | Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone | Ebola | 11,323+ | [277][278][279] |
2013–2014 chikungunya outbreak | 2013–2015 | Americas | Chikungunya | 183 | [280] |
2013–19 avian influenza epidemic | 2013–2019 | China | Influenza A virus subtype H7N9 | 616 | [281] |
21st century Madagascar plague outbreaks | 2014–2017 | Madagascar | Bubonic plague | 292 | [282] |
Flint water crisis | 2014–2015 | Flint, Michigan, United States | Legionnaires' disease | 12 | [283] |
2014 Odisha hepatitis outbreak | 2014–2015 | India | Primarily Hepatitis E, but also Hepatitis A | 36 | [284] |
2015 Indian swine flu outbreak | 2015 | India | Influenza A virus subtype H1N1 | 2,035 | [285][286][287] |
2015–16 Zika virus epidemic | 2015–2016 | Worldwide | Zika virus | 53 | [288] |
2016 Angola and Democratic Republic of the Congo yellow fever outbreak | 2016 | Angola and Democratic Republic of the Congo | Yellow fever | 498 (377 in Angola, 121 in Congo) | [289] |
2016–2022 Yemen cholera outbreak | 2016–2023 | Yemen | Cholera | 4,004 (as of June 11, 2023[update]) | [290] |
2017 Nigeria Lassa fever epidemic | 2017–2023 | Nigeria | Lassa fever | 1103 (as of April 2023) | [291] |
2017 dengue outbreak in Peshawar | 2017 | Peshawar, Pakistan | Dengue fever | 69 | [292] |
2017 Gorakhpur hospital deaths | 2017 | India | Japanese encephalitis | 1,317 | [293] |
2017 dengue outbreak in Sri Lanka | 2017 | Sri Lanka | Dengue fever | 440 | [294] |
2018 Nipah virus outbreak in Kerala | 2018 | India | Nipah virus infection | 17 | [295] |
Kivu Ebola epidemic | 2018–2020 | Democratic Republic of the Congo and Uganda | Ebola | 2,280 | [296][297][298] |
2018 NDM-CRE outbreak in Italy | 2018–2019 | Italy | New Delhi metallo-beta-lactamase-producing Carbapenem-resistant enterobacteriaceae | 31 (as of September 2019) | [299] |
2019–2020 measles outbreak in the Democratic Republic of the Congo | 2019–2020 | Democratic Republic of the Congo | Measles | 7,018+ | [300] |
2019–2020 New Zealand measles outbreak | 2019–2020 | New Zealand | Measles | 2 | [301] |
2019 measles outbreak in the Philippines | 2019 | Philippines | Measles | 415 | [302] |
2019 Kuala Koh measles outbreak | 2019 | Kuala Koh, Malaysia | Measles | 15 | [303] |
2019 Samoa measles outbreak | 2019 | Samoa | Measles | 83 | [304] |
2019–2020 dengue fever epidemic | 2019–2020 | Asia-Pacific, Latin America | Dengue fever | 3,931 | [305] |
COVID-19 pandemic | 2019[b]–present | Worldwide | COVID-19 | 7–35 million | [10] |
2020 Democratic Republic of the Congo Ebola outbreak | 2020 | Democratic Republic of the Congo | Ebola | 55 | [307] |
2020 dengue outbreak in Singapore | 2020 | Singapore | Dengue fever | 32 | [308] |
2020 Nigeria yellow fever epidemic | 2020 | Nigeria | Yellow fever | 296 (as of 31 December 2020) | [309] |
2021 India black fungus epidemic | 2021–2022 | India | Black fungus (COVID-19 condition) | 4,332 | [310] |
2022 hepatitis of unknown origin in children | 2021–2022 | Worldwide | Hepatitis by Adenovirus variant AF41 (Unconfirmed) | 18 | [311][312][313] |
2022–2023 mpox outbreak | 2022–2023 | Worldwide | Monkeypox virus | 280 | [314][315][316][317] |
2022 Uganda Ebola outbreak | 2022–2023 | Uganda | Sudan ebolavirus | 77 | [318] |
2023 South Poland Legionellosis outbreak | 2023 | Poland | Legionnaires' disease | 41 | [319][320] |
2023 dengue epidemic in Brazil | 2023–present | Brazil | Dengue virus | 1625 | |
2023–2024 Bangsamoro measles outbreak | 2023–present | Bangsamoro, Philippines | Measles | 14 | |
2024 dengue epidemic in Argentina | 2024–present | Argentina | Dengue virus | 238 | [321] |