Kaempferide

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.[1]

Kaempferide
Kaempferide structure
Names
IUPAC name
3,5,7-Trihydroxy-4′-methoxyflavone
Systematic IUPAC name
3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Other names
Kaempferid
4′-Methylkaempferol
Kaempferol 4′-methyl ether
4′-O-Methylkaempferol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.007.036 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 ☒N
    Key: SQFSKOYWJBQGKQ-UHFFFAOYSA-N ☒N
  • InChI=1/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
    Key: SQFSKOYWJBQGKQ-UHFFFAOYAC
  • COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
  • COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Properties
C16H12O6
Molar mass300.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Metabolism

The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.

Glycosides

Icariin is the tert-amyl alcohol derivative of kaempferide 3,7-O-diglycoside.

References


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