Keratin 2A

Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.^[5][6]

KRT2
Identifiers
Aliases	KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE, keratin 2
External IDs	OMIM: 600194; MGI: 96699; HomoloGene: 30974; GeneCards: KRT2; OMA:KRT2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,644,558 bp[1] End 52,652,211 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.03 cM Start 101,719,124 bp[2] End 101,726,604 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of thigh skin of hip skin of abdomen nipple human penis gingival epithelium vulva palpebral conjunctiva gastrocnemius muscle Top expressed in skin of external ear lip dentate gyrus of hippocampal formation granule cell ankle ankle joint Ileal epithelium entorhinal cortex filiform papilla stellate ganglion ganglion of vagus nerve More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of cytoskeleton protein binding structural molecule activity cytoskeletal protein binding structural constituent of skin epidermis Cellular component keratin filament extracellular exosome membrane nucleus intermediate filament extracellular space cytosol cornified envelope Biological process keratinocyte migration keratinocyte activation keratinocyte proliferation intermediate filament organization epidermis development keratinocyte development keratinization cornification peptide cross-linking positive regulation of epidermis development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3849 16681 Ensembl ENSG00000172867 ENSMUSG00000064201 UniProt P35908 Q3TTY5 RefSeq (mRNA) NM_000423 NM_010668 RefSeq (protein) NP_000414 NP_034798 Location (UCSC) Chr 12: 52.64 – 52.65 Mb Chr 15: 101.72 – 101.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Keratin 2A is a type II cytokeratin. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.^[7]