Isepamicin (also Isepamycin) is an aminoglycoside antibiotic.
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Other names | (2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide |
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ECHA InfoCard | 100.055.567 |
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Formula | C22H43N5O12 |
Molar mass | 569.609 g·mol−1 |
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It was patented in 1973 and approved for medical use in 1988.[1] It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.[2]
Synthesis
![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Isepamicin_synthesis.svg/500px-Isepamicin_synthesis.svg.png)
Gentamicin B [36889-15-3] (1)benzyl N-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate, PC70561099 (2)(3)