Interleukin-6 receptor

IL6R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N26, 1P9M, 2ARW
Identifiers
Aliases	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor
External IDs	OMIM: 147880; MGI: 105304; HomoloGene: 474; GeneCards: IL6R; OMA:IL6R - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	154,469,450 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,820,503 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; right lobe of liver; ; gastrocnemius muscle; ; granulocyte; ; trabecular bone; ; bone marrow cells; ; synovial joint; ; saphenous vein; ; gastric mucosa;
	Top expressed in
	granulocyte; ; blood; ; islet of Langerhans; ; decidua; ; muscle of thigh; ; lip; ; left lobe of liver; ; tibiofemoral joint; ; esophagus; ; lymph node;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ciliary neurotrophic factor receptor activity; protein homodimerization activity; interleukin-6 receptor binding; protein binding; cytokine receptor activity; enzyme binding; ciliary neurotrophic factor binding; interleukin-6 receptor activity; interleukin-6 binding; interleukin-12 receptor binding; growth factor activity; cytokine binding; interleukin-12 alpha subunit binding; interleukin-23 receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; basolateral plasma membrane; apical plasma membrane; interleukin-6 receptor complex; ciliary neurotrophic factor receptor complex; extracellular space; cell surface; external side of plasma membrane; receptor complex; interleukin-12 complex; interleukin-23 complex;
Biological process	positive regulation of activation of Janus kinase activity; response to cytokine; hepatic immune response; extrinsic apoptotic signaling pathway; monocyte chemotaxis; ciliary neurotrophic factor-mediated signaling pathway; positive regulation of leukocyte chemotaxis; negative regulation of interleukin-8 production; positive regulation of osteoblast differentiation; defense response to Gram-negative bacterium; acute-phase response; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell population proliferation; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of chemokine production; neutrophil mediated immunity; negative regulation of collagen biosynthetic process; endocrine pancreas development; positive regulation of MAPK cascade; positive regulation of smooth muscle cell proliferation; defense response to Gram-positive bacterium; positive regulation of tyrosine phosphorylation of STAT protein; cytokine-mediated signaling pathway; interleukin-6-mediated signaling pathway; positive regulation of T-helper 1 type immune response; regulation of signaling receptor activity; positive regulation of interferon-gamma production; positive regulation of natural killer cell activation; positive regulation of activated T cell proliferation; positive regulation of lymphocyte proliferation; positive regulation of NK T cell activation; positive regulation of glomerular mesangial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3570
	16194
	ENSG00000160712
	ENSMUSG00000027947
	P08887
	P22272
	NM_000565; NM_001206866; NM_181359
	NM_010559; NM_001310676
NP_000556; NP_001193795; NP_852004; NP_001369698; NP_001369699;
	NP_001369700; NP_001369701; NP_001369702; NP_001369703
	NP_001297605; NP_034689
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Function

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytes IL6R gene expression may be regulated by MITF.^[5]

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[6] IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6^[7]^[8]^[9] and ciliary neurotrophic factor.^[8]^[10]

References

External links

IL6R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Search

Interleukin-6 receptor

Contents

Function

Structure

Interactions

See also

References

Further reading

External links