IgSF CAM

Junctional adhesion molecules
Junctional adhesion molecules
Identifiers
Symbol	JAM
InterPro	IPR029871
Membranome	212

Immunoglobulin-like adhesion molecules
Immunoglobulin-like adhesion molecules
Identifiers
Symbol	IgSF CAM
Membranome	221

IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are cell adhesion molecules that belong to Immunoglobulin superfamily.^[1] It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety. This family is involved in both homophilic or heterophilic binding and has the ability to bind integrins or different IgSF CAMs.

Examples

Here is a list of some molecules of this family:

NCAMs Neural Cell Adhesion Molecules
ICAM-1 Intercellular Cell Adhesion Molecule
VCAM-1 Vascular Cell Adhesion Molecule
PECAM-1 Platelet-endothelial Cell Adhesion Molecule
MAdCAM-1 Mucosal Vascular Addressin Cell Adhesion Molecule
L1 family including L1 (protein), CHL1, Neurofascin and NrCAM
SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83
CTX family including CTX, Junctional adhesion molecule (JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM
Nectins and related proteins, including CADM1 and other Synaptic Cell Adhesion Molecules
CD2
CD48
HEPACAM
HEPACAM2
DSCAM - Down syndrome cell adhesion molecule

References

[1]