INTS6

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.^[5][6][7]

INTS6
Identifiers
Aliases	INTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDs	OMIM: 604331; MGI: 1202397; HomoloGene: 8121; GeneCards: INTS6; OMA:INTS6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 51,354,077 bp[1] End 51,454,264 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 62,913,779 bp[2] End 62,998,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon optic nerve right testis left testis epithelium of colon tonsil body of pancreas ventricular zone gingival epithelium Top expressed in spermatocyte spermatid tail of embryo seminiferous tubule Gonadal ridge lacrimal gland genital tubercle human fetus gastrula cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity Cellular component integrator complex actin cytoskeleton nucleoplasm nucleus Biological process snRNA processing snRNA transcription by RNA polymerase II signal transduction snRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26512 18130 Ensembl ENSG00000102786 ENSMUSG00000035161 UniProt Q9UL03 Q6PCM2 RefSeq (mRNA) NM_001039937 NM_001039938 NM_001306091 NM_012141 NM_008715 RefSeq (protein) NP_001035026 NP_001035027 NP_001293020 NP_036273 NP_032741 Location (UCSC) Chr 13: 51.35 – 51.45 Mb Chr 14: 62.91 – 63 Mb PubMed search [3] [4]
Wikidata
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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.^[7]