IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.^[5][6][7]

IGF2BP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E44
Identifiers
Aliases	IGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3
External IDs	OMIM: 608259; MGI: 1890359; HomoloGene: 4773; GeneCards: IGF2BP3; OMA:IGF2BP3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 23,310,209 bp[1] End 23,470,491 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B2.3|6 23.82 cM Start 49,062,157 bp[2] End 49,191,891 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid buccal mucosa cell placenta embryo sperm ventricular zone ganglionic eminence monocyte cartilage tissue Top expressed in primitive streak tail of embryo mandibular prominence maxillary prominence genital tubercle somite internal carotid artery medullary collecting duct abdominal wall epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA 5'-UTR binding protein binding translation regulator activity mRNA 3'-UTR binding nucleic acid binding RNA binding Cellular component nucleus cytoplasm cytosol Biological process anatomical structure morphogenesis negative regulation of translation mRNA transport protein biosynthesis regulation of translation regulation of mRNA stability transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10643 140488 Ensembl ENSG00000136231 ENSMUSG00000029814 UniProt O00425 Q9CPN8 RefSeq (mRNA) NM_006547 NM_023670 RefSeq (protein) NP_006538 NP_076159 Location (UCSC) Chr 7: 23.31 – 23.47 Mb Chr 6: 49.06 – 49.19 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.

The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.^[7]