The Hirao coupling (also called the Hirao reaction or the Hirao cross-coupling) is the chemical reaction involving the palladium-catalyzed cross-coupling of a dialkyl phosphite and an aryl halide to form a phosphonate.[1][2][3]This reaction is named after Toshikazu Hirao and is related to the Michaelis-Arbuzov reaction. In contrast to the classic Michaelis-Arbuzov reaction, which is limited to alkyl phosphonates, the Hirao coupling can also deliver aryl phosphonates.
| Hirao coupling | |
|---|---|
| Named after | Toshikazu Hirao |
| Reaction type | Coupling reaction |