Guaira may refer to:
- Guayrá, a former region of the Spanish Empire in what is now modern Paraguay and Brazil
- Guaíra Falls, former waterfalls on the Paraná River along the border between Brazil and Paraguay
Brazil
Paraguay
- Guairá Department
- Salto del Guairá, Canindeyú Department
Venezuela
- La Guaira State
- La Guaira, its capital city
See also
- Guiara, a rodent