Gamma-aminobutyric acid receptor subunit alpha-1

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.^[5]

GABRA1
Identifiers
Aliases	GABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit, gamma-aminobutyric acid type A receptor subunit alpha1, DEE19
External IDs	OMIM: 137160; MGI: 95613; HomoloGene: 629; GeneCards: GABRA1; OMA:GABRA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34 Start 161,847,063 bp[1] End 161,899,981 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A5|11 24.97 cM Start 42,021,766 bp[2] End 42,073,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus endothelial cell middle temporal gyrus Brodmann area 23 superior frontal gyrus primary visual cortex postcentral gyrus frontal pole external globus pallidus prefrontal cortex Top expressed in lobe of cerebellum cerebellar vermis deep cerebellar nuclei globus pallidus lateral septal nucleus lateral hypothalamus ventral tegmental area medial geniculate nucleus dorsal tegmental nucleus medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity GABA receptor activity chloride channel activity extracellular ligand-gated ion channel activity GABA-gated chloride ion channel activity GABA-A receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential transmembrane signaling receptor activity inhibitory extracellular ligand-gated ion channel activity benzodiazepine receptor activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane integral component of plasma membrane synapse chloride channel complex cell junction GABA receptor complex cytoplasmic vesicle membrane cytoplasmic vesicle GABA-A receptor complex GABA-ergic synapse integral component of postsynaptic specialization membrane dendrite membrane neuron projection postsynapse Biological process gamma-aminobutyric acid signaling pathway synaptic transmission, GABAergic ion transport chloride transport cellular response to histamine chloride transmembrane transport regulation of postsynaptic membrane potential ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential nervous system process inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2554 14394 Ensembl ENSG00000022355 ENSMUSG00000010803 UniProt P14867 P62812 RefSeq (mRNA) NM_001127648 NM_000806 NM_001127643 NM_001127644 NM_001127645 NM_001127646 NM_001127647 NM_010250 NM_001359035 RefSeq (protein) NP_000797 NP_001121115 NP_001121116 NP_001121117 NP_001121120 NP_034380 NP_001345964 Location (UCSC) Chr 5: 161.85 – 161.9 Mb Chr 11: 42.02 – 42.07 Mb PubMed search [3] [4]
Wikidata
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.^[6]

The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.