The τ and γ subunits are part of the DNA polymerase III holoenzyme of prokaryotes. The protein family is characterized by the well-conserved first N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is replication factor C, with the subunits RFC1, RFC2, RFC3, RFC4, and RFC5.
| DNA polymerase III tau subunit V interacting with alpha | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DNA_pol_III_sug/sutau | ||||||||
| Pfam | PF12170 | ||||||||
| InterPro | IPR012763 | ||||||||
| |||||||||
The domain is also found in plants as gene STICHEL (STI), with similarity to cyanobacterial sequences.[1] However, STI in plants is nuclear-localized and does not participate in genome duplication. It seems to instead regulate branching.[2]