Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.[5]
| DLGAP1 |
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| Identifiers |
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| Aliases | DLGAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP, discs large homolog associated protein 1, DLG associated protein 1 |
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| External IDs | OMIM: 605445; MGI: 1346065; HomoloGene: 31258; GeneCards: DLGAP1; OMA:DLGAP1 - orthologs |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Brodmann area 23
- endothelial cell
- primary visual cortex
- prefrontal cortex
- pons
- dorsolateral prefrontal cortex
- Brodmann area 9
- parietal lobe
- superior frontal gyrus
- right frontal lobe
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| | Top expressed in | - piriform cortex
- subiculum
- primary motor cortex
- cingulate gyrus
- subdivision of hippocampus
- Region I of hippocampus proper
- lateral septal nucleus
- cerebellar vermis
- lobe of cerebellum
- anterior amygdaloid area
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Function
This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK2 and PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons.[6] Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.
Interactions
DLGAP1 has been shown to interact with:
The interaction with PSD95 and S-SCAM is mediated by the GUK domain[13] and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.
References
Further reading
