DAPK3

DAPK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YRP, 2J90, 3BHY, 3BQR, 5A6O, 5A6N
Identifiers
Aliases	DAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDs	OMIM: 603289; MGI: 1203520; HomoloGene: 20353; GeneCards: DAPK3; OMA:DAPK3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,971,123 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,029,031 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; stromal cell of endometrium; ; right auricle; ; muscle layer of sigmoid colon; ; muscle of thigh; ; body of uterus;
	Top expressed in
	yolk sac; ; muscle of thigh; ; lip; ; right kidney; ; superior frontal gyrus; ; primary visual cortex; ; granulocyte; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; cAMP response element binding protein binding; kinase activity; protein serine/threonine kinase activity; leucine zipper domain binding; protein binding; identical protein binding; ATP binding; protein C-terminus binding;
Cellular component	PML body; actin filament; membrane raft; nucleus; cytoplasm;
Biological process	regulation of apoptotic process; regulation of actin cytoskeleton reorganization; negative regulation of translation; intracellular signal transduction; regulation of transcription, DNA-templated; regulation of smooth muscle contraction; phosphorylation; positive regulation of cell migration; positive regulation of canonical Wnt signaling pathway; regulation of myosin II filament organization; transcription, DNA-templated; regulation of cell motility; protein phosphorylation; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; regulation of autophagy; neuron differentiation; regulation of mitotic cell cycle; regulation of cell shape; positive regulation of apoptotic process; regulation of focal adhesion assembly; cellular response to interferon-gamma; apoptotic signaling pathway; protein autophosphorylation; regulation of translation; regulation of mitotic nuclear division; apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	1613
	13144
	ENSG00000167657
	ENSMUSG00000034974
	O43293
	O54784
	NM_001348; NM_001375658
	NM_001190473; NM_001190474; NM_007828
	NP_001339; NP_001362587
	NP_001177402; NP_001177403; NP_031854
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.^[5]^[6]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[7]

Interactions

DAPK3 has been shown to interact with PAWR^[8] and Death associated protein 6.^[8]

Search

DAPK3

Contents

Function

Interactions

References

Further reading