ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (CTGF) messenger RNA.[1] This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).
| ctgf/hcs24 CAESAR | |
|---|---|
 Predicted secondary structure and sequence conservation of CAESAR | |
| Identifiers | |
| Symbol | CAESAR |
| Rfam | RF00172 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000233 |
| PDB structures | PDBe |
The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised[1] and subsequently the minimal RNA element responsible for repression was identified[2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).
The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.[3]