CRTC3

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.^[5][6][7]

CRTC3
Identifiers
Aliases	CRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDs	OMIM: 608986; MGI: 1917711; HomoloGene: 11248; GeneCards: CRTC3; OMA:CRTC3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,529,923 bp[1] End 90,645,345 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2- D3 Start 80,236,375 bp[2] End 80,338,625 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell saphenous vein parotid gland visceral pleura urethra inferior olivary nucleus parietal pleura dorsal motor nucleus of vagus nerve nipple popliteal artery Top expressed in zygote internal carotid artery external carotid artery sciatic nerve Gonadal ridge secondary oocyte Rostral migratory stream genital tubercle lacrimal gland mesenteric lymph nodes More reference expression data BioGPS n/a
Gene ontology Molecular function cAMP response element binding protein binding protein binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process energy homeostasis macrophage activation positive regulation of CREB transcription factor activity viral process negative regulation of lipid catabolic process regulation of transcription, DNA-templated protein homotetramerization negative regulation of cAMP-mediated signaling transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64784 70461 Ensembl ENSG00000140577 ENSMUSG00000030527 UniProt Q6UUV7 Q91X84 RefSeq (mRNA) NM_001042574 NM_022769 NM_173863 RefSeq (protein) NP_001036039 NP_073606 NP_776288 Location (UCSC) Chr 15: 90.53 – 90.65 Mb Chr 7: 80.24 – 80.34 Mb PubMed search [3] [4]
Wikidata
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This gene has been shown to be linked to weight gain.^[8]