CD1A

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene.^[3]

CD1A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1ONQ, 1XZ0, 4X6C, 4X6D, 4X6E, 4X6F
Identifiers
Aliases	CD1A, CD1, FCB6, HTA1, R4, T6, CD1a molecule
External IDs	OMIM: 188370; HomoloGene: 113556; GeneCards: CD1A; OMA:CD1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 158,254,424 bp[1] End 158,258,269 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus skin of thigh skin of hip testicle skin of arm gums gingival epithelium skin of abdomen monocyte vulva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-2-microglobulin binding endogenous lipid antigen binding protein binding exogenous lipid antigen binding lipopeptide binding Cellular component integral component of membrane membrane raft endosome integral component of plasma membrane endosome membrane membrane plasma membrane cell surface extracellular space external side of plasma membrane Biological process antigen processing and presentation, exogenous lipid antigen via MHC class Ib adaptive immune response immune system process immune response regulation of immune response positive regulation of T cell mediated cytotoxicity antigen processing and presentation, endogenous lipid antigen via MHC class Ib Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 909 n/a Ensembl ENSG00000158477 n/a UniProt P06126 n/a RefSeq (mRNA) NM_001763 NM_001320652 n/a RefSeq (protein) NP_001307581 NP_001754 n/a Location (UCSC) Chr 1: 158.25 – 158.26 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.^[3] Transcript levels of the CD1A gene are upregulated in the lung parenchyma of smokers.^[4]