Biphenylindanone A

Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.

Biphenylindanone A

Clinical data
ATC code	none
Identifiers
IUPAC name 3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid
CAS Number	866823-73-6 Y
PubChem CID	9868580
IUPHAR/BPS	3954
ChemSpider	8044271 Y
ChEMBL	ChEMBL593013 Y
CompTox Dashboard (EPA)	DTXSID90432098
Chemical and physical data
Formula	C30H30O4
Molar mass	454.566 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cc(C(O)=O)ccc3-c(ccc4)cc4COc(c1C)cc(c(C2=O)c1C)CC2C5CCCC5
InChI InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33) Y Key:KMKBEESNZAPKMP-UHFFFAOYSA-N Y
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In animal studies it showed anxiolytic and antipsychotic effects,^[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.^[2]

BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR_2/3 agonist LY-379,268.^[3]