A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.[5][6] It is encoded by the TNFSF13 gene.[6]
TNFSF13 |
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Identifiers |
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Aliases | TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13, TNF superfamily member 13 |
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External IDs | OMIM: 604472; MGI: 1916833; HomoloGene: 56971; GeneCards: TNFSF13; OMA:TNFSF13 - orthologs |
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Wikidata |
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Nomenclature
Function
The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development.[7] However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival.[8] In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.[9] Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Interactions
Clinical significance
APRIL is being explored as a target for autoimmune diseases and B cell malignancies.[12] At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma.[13]
References
Further reading
External links